Abstract：Objective To analyze the mutation status and clinic characteristics of breast cancer susceptibility gene(BRCA)1/2 in patients with triple-negative breast cancer(TNBC).Methods From April 2017 to April 2019,55 patients with TNBC treated in our hospital were selected as the research objects.Reverse transcription polymerase chain reaction (PCR)method and DNA sequence sequencing method were used to determine the mutation of BRCA1/2 gene on the pathological tissue sections of all patients.Analyze the characteristics of BRCA1/2 gene mutation in TNBCpatients,and divide them into mutation group and non-mutation group according to whether there are gene mutations,and the clinical data of the two groups of patients were compared and analyzed.Results A total of 9 cases of BRCA1/2 gene mutation were detected in 55 patients with TNBC,including 6 cases of BRCA1 gene mutation and 3 cases of BRCA2 gene mutation,the total detection rate was 16.36%.There were no significant differences in the age,menstrual status,tumor size,pathological type,lymph node metastasis,and clinical stage between the mutation group and the non-mutation group (P＞0.05).The proportion of breast cancer family history in the mutation group was higher than that in the non-mutation group,and the difference was statistically significant(P＜0.05).Conclusion The incidence of BRCA1/2 gene mutation is higher in TNBC patients,and the proportion of breast cancer family history in patients with BRCA1/2 gene mutation is higher.
王艺诺 金锋. 三阴性乳腺癌患者BRCA1/2基因突变状态及其临床特征分析[J]. 中国当代医药, 2020, 27(24): 127-130.
WANGYi-nuo JIN Feng▲. Analysis of BRCA1/2 gene mutation status and clinic characteristics in patients with triple-negative breast cancer. 中国当代医药, 2020, 27(24): 127-130.
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