孕前及孕期妇女甲状腺功能减退筛查对妊娠结局的影响

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摘要目的探讨孕前及孕期妇女甲状腺功能减退筛查对妊娠结局的影响。方法选取2017年7月～2019年11月瑞金市妇幼保健院孕前及孕期妇女300 例的临床资料进行回顾分析，以未参与甲状腺功能减退筛查的150 例妇女为对照组，以参与甲状腺功能减退筛查的150 例妇女为观察组。比较两组的不良妊娠发生率、甲状腺功能减退发生率及胎儿发育受限发生率。结果 300 例孕前及孕期妇女检测结果显示，甲状腺功能减退患者37 例，其发生率为12.33%。观察组的甲状腺功能减退发生率为11.33%，对照组发生率为13.33%，两组甲状腺功能减退发生率比较，差异无统计学意义（P＞0.05）；观察组的胎儿发育受限率（1.33%）低于对照组（6.00%），差异有统计学意（P＜0.05）；观察组的流产、早产、妊娠高血压综合征、胎盘早剥、低体重儿等不良妊娠结局总发生率低于对照组，差异有统计学意义（P＜0.05）。结论对孕前及孕期妇女行甲状腺功能减退筛查，可有效改善妇女妊娠结局，促进胎儿正常发育，值得推广。

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	李昇容
	黄金秋
	李琴

关键词 ：孕前及孕期妇女, 甲状腺功能减退, 妊娠结局, 胎儿发育受限结局, 早期筛查效果

Abstract：Objective To explore the effect of hypothyroidism screening on pregnancy outcome before and during pregnancy. Methods The clinical data of 300 women before and during pregnancy in Maternal and Child Health Hospital of Ruijin City from July 2017 to November 2019 were selected for retrospective analysis, 150 women who did not participate in the hypothyroidism screening were selected as the control group, and 150 women who participate in the hypothyroidism screening were selected as the observation group. The incidence of adverse pregnancy, hypothyroidism and fetal growth restriction between the two groups were compared. Results The test results of 300 women before and during pregnancy showed that there were 37 cases of hypothyroidism, and the incidence was 12.33%. The incidence of hypothyroidism in the observation group was 11.33%, while that in the control group was 13.33%, there was no significant difference in the incidence of hypothyroidism between the two groups (P＞0.05). The rate of fetal growth restriction in the observation group (1.33%) was lower than that in the control group (6.00%), the difference was statistically significant (P＜0.05). The total incidence of adverse pregnancy outcomes as abortion, premature delivery, pregnancy induced hypertension syndrome, placental abruption and low birth weight infants in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The screening of hypothyroidism before and during pregnancy can effectively improve the pregnancy outcome and promote the normal development of fetus, which is worthy of promotion.

Key words： Women before and during pregnancy Hypothyroidism Pregnancy outcome Fetal growth restriction outcome Early screening effect

基金资助:江西省赣州市指导性科技计划项目（GZ2019ZSF 511）

引用本文:

李昇容；黄金秋；李琴. 孕前及孕期妇女甲状腺功能减退筛查对妊娠结局的影响[J]. 中国当代医药, 2020, 27(28): 143-146.
LI Sheng-rong；HUANG Jin-qiu； LI Qin. Influence of hypothyroidism screening on pregnancy outcome before and during pregnancy. 中国当代医药, 2020, 27(28): 143-146.

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