Clinical effect of Octreotide combined with Omeprazole in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding
HU Qing-fang1 LIU Na1 XU Hong1 LI Jing-hua2
1.Department of Gastroenterology,the First Hospital of Ji′an City,Jiangxi Province,Ji′an 343000,Chian;
2.Department of Endoscope Room,the First Hospital of Ji′an City,Jiangxi Province,Ji′an 343000,Chian
Abstract：Objective To investigate the clinical effect of Octreotide combined with Omeprazole in the treatment of cirrhosis complicated with upper gastrointestinal hemorrhage.Methods A total of 60 patients with cirrhosis complicated with upper gastrointestinal bleeding admitted to our hospital from September 2015 to April 2019 were selected as study subjects,and were divided into control group (30 cases)and experimental group (30 cases)according to the random number table method.Patients in the two groups were given routine symptomatic treatment,on the basis of which the control group was treated with Omeprazole alone,while the experimental group was treated with Octreotide combined with Omeprazole.The treatment course was 1 week in both groups.After the course of treatment,the overall effective rate,hemostasis time,rebleeding rate,hospitalization time and the improvement of inflammatory factors in the two groups were observed and compared,and the total incidence of adverse reactions during treatment was recorded.Results After treatment,the overall effective rate of the experimental group was 96.67%,which was higher than that of the control group(66.67%),and the difference was statistically significant(P＜0.05).The hemostasis time and hospital stay in the experimental group were shorter than those in the control group,the bleeding rate was lower than that in the control group,with statistically significant differences (P＜0.05).The total incidence of gastrointestinal spasm,nausea and vomiting,arrhythmia,palpitations and other adverse reactions in the experimental group was 10.00%,lower than that in the control group(33.33%),with statistically significant difference(P＜0.05).Procalcitonin(PCT)([0.24±0.04]ng/ml),C-reactive protein(CRP)([8.99±0.54]mg/L),interleukin-2(IL-2)([2.76±0.55]μg/ml)and interleukin-1 levels(IL-1β)([3.00±0.77]μg/ml)in the experimental group were lower than those in the control group for the levels of PCT([0.31±0.06]ng/ml),CRP([14.23±2.01]mg/L),IL-2([3.18±0.60]μg/ml)and IL-1β([3.62±0.96]μg/ml),the differences were statistically significant(P＜0.05).Conclusion Octreotide combined with Omeprazole can effectively eliminate inflammation,shorten hemostasis time,reduce rebleeding rate,shorten hospital stay and promote the recovery of patients with cirrhosis complicated with upper gastrointestinal bleeding under the premise of ensuring the safety of treatment.
胡庆芳 刘娜 徐红 李京华. 奥曲肽联合奥美拉唑治疗肝硬化合并上消化道出血的临床效果[J]. 中国当代医药, 2020, 27(24): 87-90.
HU Qing-fang1 LIU Na1 XU Hong1 LI Jing-hua2. Clinical effect of Octreotide combined with Omeprazole in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding. 中国当代医药, 2020, 27(24): 87-90.
Rauscher I，Eiber M，Ganter C，et al.Evaluation of T1ρas a potential MR biomarker for liver cirrhosis：comparison of healthy control subjects and patients with liver cirrhosis[J].Eur JRadiol，2014，83（6）：900-904.
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