Objective To investigate the clinical significance of the changes of T lymphocyte immunity and cytokines in children with primary nephrotic syndrome (PNS). Methods A total of 30 children with PNS admitted to our hospital from June 2015 to March 2019 were selected as the research objects and divided into active group (13 cases) and remission group (17 cases) according to disease progression. Meanwhile, 30 healthy children were selected as the control group. The levels of CD3+, cytotoxic T cell (Tc), helper T cell (Th), Th/Tc and interleukin-6 (IL-6) in the three groups were compared. Results There was no statistically significant difference in CD3+level among the three groups (P>0.05).Th and Th/Tc levels in the active group and the remission group were lower than those in the control group, and the differences were statistically significant (P<0.05). Tc and IL-6 levels in the active group and the remission group were higher than those in the control group, and the differences were statistically significant (P<0.05). Th and Th/Tc levels in the active group were lower than those in the remission group, and the differences were statistically significant (P<0.05). Tc and IL-6 levels in the active group were higher than those in the remission group, and the differences were statistically significant (P<0.05). IL-6 was positively correlated with Tc (r=0.91, P<0.01), negatively correlated with Th(r=-0.92, P<0.05) and negatively correlated with Th/TC (r=-0.90, P<0.05). Conclusion There are changes in T lymphocyte subsets and cytokines in children with PNS, which may play a role in the pathogenesis of PNS.
Li J，Zhang Q，Su B.Clinical characteristics and risk factors of severe infections in hospitalized adult patients with primary nephrotic syndrome[J].J Int Med Res，2017，45（6）：2139-2145.
Li C，Yao Z，Zhu M，et al.Biopsy-Free Prediction of Pathologic Type of Primary Nephrotic Syndrome Using a Machine Learning Algorithm[J].Kidney Blood Press Res，2017，42（6）：1045-1052.
[15]
Stachowski J，Barth C，Michalkiewicz J，et al.Th1/Th2 balance and CD45-positive T cell subsets in primary nephrotic syndrome[J].Pediatr Nephrol，2000，14（8-9）：779-785.
[16]
Cos，kun，ztopuz，zkanF.Determination of IL-6，TNF-α and VEGF levels in the serums of patients with colorectal cancer[J].Cell Mol Biol，2017，63（5）：97-101.
[17]
Nishikimi A，Koyama YI，Ishihara S，et al.Collagen-derived peptides modulate CD4+T-cell differentiation and suppress allergic responses in mice：suppression of allergic responses by collagen peptides[J].Immun Inflamm Dis，2018，6（2）：245-255.
京公网安备 11010502046607号