Abstract：Objective To explore the clinical effect of Entecavir and Adefovir Dipivoxil in the treatment of chronic hepatitis B.Methods A total of 60 patients with chronic hepatitis B who were admitted to our hospital from February 2018 to February 2019 were selected as the research objects.and they were divided into observation group (odd number patients)and control group (even number patients)using the single and double number method,30 cases in each group.Patients in the control group were treated with Adefovir Dipivoxil,and patients in the observation group were treated with Entecavir combined with Adefovir Dipivoxil.The levels of total bilirubin (TBil),alanine aminotransferase(ALT)and albumin(ALB),the total effective rate of clinical treatment,and the total incidence of adverse reactions were compared between the two groups of patients before and after treatment.Results There were no significant differences in TBil,ALT and ALB between the two groups before treatment(P＞0.05).After treatment,the levels of TBil and ALT in the observation group were lower than those in the control group,while the level of ALB was higher than that in the control group,with statistically significant differences (P＜0.05).The total effective rate of the test group was 93.00%,higher than that of the control group(70.00%),and the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Entecavir combined with Adefovir Dipivoxil in the treatment of chronic hepatitis B can effectively improve the level of TBil,ALT and ALB,and increase the total effective rate of clinical treatment.and reduce the incidence of adverse reactions.It is worthy of clinical application
王燕燕. 恩替卡韦联合阿德福韦酯治疗慢性乙型肝炎的临床效果[J]. 中国当代医药, 2020, 27(24): 59-61.
WANGYan-yan. Clinical effect of Entecavir combined with Adefovir Dipivoxil in the treatment of chronic hepatitis B. 中国当代医药, 2020, 27(24): 59-61.
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