Objective To explore the effect of Omaha system in patients with chronic heart failure. Methods A total of 80 patients with chronic heart failure admitted to Jinzhou Central Hospital from February 2018 to March 2020 were selected as the research objects, and they were divided into the control group and the observation group according to lottery method, with 40 patients in each group. Patients in the control group received routine care, and patients in the observation group received care based on the Omaha system. The distribution of nursing problems, the effectiveness evaluation of nursing problems and quality of life score were compared between the two groups. Results Three months after discharge, the incidence of nursing problems in the fields of social psychology, physiology and health-related behavior in the control group were higher than those in the same group during hospitalization, the differences were statistically significant (P＜0.05). Three months after discharge, the incidence of nursing problems in the fields of social psychology, physiology and health-related behavior in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).At discharge,scores of mental state,respiratory state,pain,circulatory system, nutritional status, physical activity, self-care and drug abuse nursing problems in the two groups were higher than those in the same group on the first day of admission, the differences were statistically significant (P＜0.05). At discharge, the scores of mental state, respiratory state, pain, circulatory system, nutritional status, physical activity,self-care and drug abuse nursing problems in the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05). Three months after discharge, the scores of clinical symptoms,physical activity and emotional state in the two groups were lower than those in the same group, the differences were statistically significant (P＜0.05). Three months after discharge, the clinical symptoms, physical activity and emotional state scores of patients in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Omaha system application and chronic heart failure patients can reduce the incidence of nursing problems, improve the quality of life of patients, worthy of clinical application.