Clinical effect of Sofren Injection in the treatment of patients with advanced non-small cell lung cancer
ZHOU Xiao-long1 CHENG Wen-na1 ZHANGJing-yi2▲
1.Department of Pharmacy,Binzhou Medical University Hospital,Shandong Province,Binzhou 256601,China;
2.Department of Pharmacy,the First Hospital of Zibo City,Shandong Province,Zibo 255200,China
Abstract：Objective To explore the clinical effect of Sofren Injection in the treatment of patients with advanced nonsmall cell lung cancer(NSCLC).Methods A total of 120 patients with advanced NSCLC admitted to the Binzhou Medical University Hospital from January to December 2018 were selected as study subjects,and were divided into the control group and the treatment group by the random number table method,with 60 patients in each group.All patients were divided into control group and treatment group by the random number table method,with 60 patients in each group.The control group was given Compound Sophora Flavescens Injection and symptomatic treatment,and the treatment group was given Sofren Injection on this basis.The levels of serum tumor markers,traditional Chinese medicine symptom scores and immune function indexes before and after treatment were compared between the two groups.The short-term efficacy was compared between the two groups.Quality of life scores before and after treatment were compared between the two groups.Results The levels of carcinoembryonic antigen (CEA),cytokeratin 19 fragment(CYFRA21-1),carbohydrate antigen 19-9(CA19-9),and neuron-specific enolase(NSE)in the two groups were lower than those before treatment,with statistically significant differences (P＜0.05).After treatment,CEA,CYFRA21-1,CA19-9 and NSE in the treatment group were all lower than those in the control group,with statistically significant differences (P＜0.05).The scores of traditional Chinese medicine symptoms of cough and expectoration of sputum,chest congestion and shortness of breath,abdominal distension and stupor,nausea and vomiting,and limb weakness in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The scores of traditional Chinese medicine symptoms of cough and expectoration of sputum,chest congestion and shortness of breath,abdominal distension and stupor,nausea and vomiting,and limb weakness in the treatment group were lower than those in the control group,with statistically significant differences(P＜0.05).The total effective rate and stability of the treatment group were higher than those of the control group,and the differences were statistically significant(P＜0.05).The total effective rate and stability of the treatment group were higher than those of the control group,and the difference was statistically significant(P＜0.05).After treatment,CD4+and CD4+/CD8+in the two groups were higher than those before treatment,and CD8+was lower than that before treatment,with statistically significant differences (P＜0.05).After treatment,CD4+and CD4+/CD8+in the treatment group were higher than those in the control group,and CD8+was lower than that in the control group,with statistically significant differences(P＜0.05).The scores of dyspnea,anorexia,cough,hemoptysis and pain in the treatment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Sofren Injection can significantly alleviate traditional Chinese medicine symptoms of patients with advanced NSCLC,and significantly improve the clinical treatment effect of patients with intermediate and advanced lung cancer,it can improve the immune function,and improve the clinical symptoms.It is worthy of clinical application.
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