Objective To explore the application effect of maximum Phloroglucinol in the labor process of premature rupture of membranes with poor cervical conditions. Methods From January 2020 to January 2021, 120 pregnant women with premature rupture of membranes admitted to Dalian Women and Children′s Medical Center(Group) who required natural childbirth and cervical Bishop score less than 6 scores were selected as the research objects.According to the sequence of their coming to the hospital, they were assignned to the first maternity ward and other obstetric wards. Among them,60 parturients in the first maternity ward were in the observation group,and they were given Phloroglucinol 200 mg+Diazepam 10 mg. The rest of 60 pregnant women in other obstetric wards were selected as the control group and were only given Diazepam 10 mg. The progress of labor process was observed routinely. The cervical dilatation rate, labor process time, vaginal delivery rate, conversion to cesarean section rate, postpartum hemorrhage, intrauterine infection rate and neonatal Apgar score were compared between the two groups. Results The cervical dilatation rate and vaginal delivery rate in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The rate of conversion to cesarean section and intrauterine infection in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The latency and active period of the first stage of labor in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The amount of postpartum hemorrhage at 2 hours after delivery in the observation group was less than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the second stage of labor and neonatal Apgar score between the two groups (P＞0.05). Conclusion Maximum Phloroglucinol combined with Diazepam can accelerate the expansion of uterine orifice, shorten the latency and active period of the first stage of labor process, improve the vaginal delivery rate, reduce the conversion rate of cesarean section and the amount of postpartum hemorrhage, and have no significant effect on the outcome of newborns.