Objective To explore the clinical effect of Pantoprazole combined with Qizhi Weitong Granules combined with lifestyle regulation in the treatment of elderly patients with gastroesophageal reflux disease.Methods A retrospective study was conducted between September 2019 to September 2021, a total of 140 elderly patients with GERD who were treated in Peking University Hospital were recruited, according to the drug treatment regimen is divided into observation group (70 cases) and control group (70 cases). The observation group was treated with Pantoprazole combined with Qizhi Weitong Granules combined with lifestyle regulation for comprehensive treatment, while the control group was treated with Pantoprazole combined with lifestyle regulation for comprehensive treatment. The clinical effects of the two groups were evaluated from the two evaluation systems of traditional Chinese medicine and Western medicine, and the improvement of symptoms, traditional Chinese medicine syndrome efficacy, quality of life and adverse reactions of the two groups were compared. Result After treatment, the reflux disease questionnaire scores and gastroesophageal reflux disease health-related quality of life scale scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The total effective rate of syndrome treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion After effective regulation of lifestyle, the combined treatment of Pantoprazole and Qizhi Weitong Granules in elderly patients with gastroesophageal reflux disease can improve therapeutic effect, curative effects on gastroesophageal reflux disease symptoms, health-related quality of life and reduce incidence of adverse effects. The treatment was worthy of clinical application.