With the progress of medical technology, the survival rate of women of childbearing age with malignant diseases has been significantly improved after treatment, and the demand for a good quality of life after the disease has become increasingly strong. Premature ovarian failure (POF) after hematopoietic stem cell transplantation (HSCT) has been an important reason for the improvement of patients′ quality of life. Based on the clinical experience of professor Lei Lei, this paper discusses the possibility of integrated traditional Chinese and Western medicine in improving POF after HSCT. Professor Lei Lei treats from deficiency, takes tonifying as the method, applies Jiawei Sierwu prescription combined with hormone replacement therapy, supplemented by traditional Chinese medicine retention enema, and pays attention to the treatment of body and mind at the same time, so as to provide a more efficient and safer way for clinical treatment of related diseases.