Abstract：Objective To investigate the changes and clinical significance of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (γ-GT) in patients with cirrhosis. Methods A total of 40 patients with liver cirrhosis diagnosed in the Department of Laboratory, the Third Affiliated Hospital of Sun Yat-Sen University Yuedong Hospital from January 2019 to December 2020 were selected as the research objects, and 20 healthy people who underwent physical examination in the Third Affiliated Hospital of Sun Yat-Sen University Yuedong Hospital in the same period were selected as the control group. The AST, ALT and γ-GT tests were performed respectively. AST,ALT, γ-GT, cholinesterase (CHE), total protein (TP), albumin (ALB), albumin/globulin (A/G), alpha fetoprotein (AFP),glutamate dehydrogenase (GLDH), adenosine deaminase (ADA), a-algae glycosidase (AFU), J3-N-acetylglucosidase(NAG) and leucine aminopeptidase (LAP) levels were cmpared between the two groups. Results The levels of AST, ALT and γ-GT in experimental group were higher than those in control group, and the differences were statistically significant (P<0.05). The levels of AFP, GLDH, ADA, AFU, NAG and LAP in experimental group were higher than those in control group, and the differences were statistically significant (P<0.05). The levels of ALB, TP, CHE and A/G in experimental group were lower than those in control group, and the differences were statistically significant (P<0.05).Conclusion AST, ALT and γ-GT is a sensitive index for the examination and diagnosis of liver cirrhosis, which can provide basis for disease diagnosis.
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