Abstract: Objective To explore the application effect of thunder fire moxibustion combined with moist burn ointment in 2nd and 3rd stage pressure injuries. Methods A total of 60 patients with stage 2 and stage 3 pressure injuries who were admitted to the Department of Neurology, Yangjiang Hospital of Traditional Chinese Medicine from October 2020 to May 2021 were selected as the research objects. They were divide into control group and observation group according to random envelope method, with 30 cases in each group. The control group was treated with pressure injury care combined with moist burn ointment for external application, and the observation group was combined with thunder fire moxibustion on the basis of the control group, and the pressure ulcer scale for healing (PUSH) was used to evaluate the pressure injury recovery of the two groups. The growth of granulation tissue in the two groups was evaluated at 3, 7, and 14 d after nursing, and the dressing changes times, pressure injury healing time and adverse reactions were compared between the two groups. Results There were no stastically significances in PUSH scores between two groups before nursing (P>0.05). After nursing, the PUSH score of the observation group was lower than that of the control group, the difference was statistically significant (P<0.05). The observation group's granulation tissue growth scores at 3, 7 d after nursing were lower than those of control group, the differences were statistically significant (P<0.05). The granulation tissue growth scores of two groups at 14 d after nursing were not statistically significant (P>0.05). The observation group's dressing changes times were fewer than those of control group, and the pressure injury healing time was shorter than that of control group, the differences were statistically significant (P<0.05). No serious adverse reactions occurred in the two groups. Conclusion The combination of thunder fire moxibustion and moist burn ointment can improve the healing of pressure injuries, accelerate the growth of granulation tissue, reduce the times of dressing changes, shorten the healing time, and have high safety in stage 2 and 3 pressure injuries.