Abstract：Objective To investigate the effect of serratus anterior plane block on postoperative pain and immune function in patients undergoing thoracoscopic surgery. Methods A total of 70 patients who underwent thoracoscopic related surgeries admitted to Yichun People's Hospital from January 2019 to March 2021 were selected as the research subjects and were divided into serratus anterior plane block (SAPB) group (35 cases) and thoracic paravertebral block(TPVB) group (35 cases) by the random number table. The SAPB group were treated with SAPB, and the TPVB group were treated with TPVB. The use of analgesic drugs, pain scores and body immune function were compared between the two groups. Results The dose of propofol, remifentanil, and sufentanil in the SAPB group were lower than those in the TPVB group, and the differences were statistically significant (P＜0.05). The pain score of the SATB group was lower than that of the TPVB group, and the difference was statistically significant (P＜0.05). There was no significant difference in preoperative immune function between the two groups (P＞0.05). The levels of C-reactive protein (CRP), procalcitonin (PCT), CD3+, CD4+ and CD4+/CD8+ in the SATB group were lower than those in the TPVB group one day and two days after surgery, while CD8+was higher than that in the TPVB group, and the differences were statistically significant (P＜0.05). Conclusion In patients undergoing thoracoscopic surgery, SAPB has a definite effect, which can not only reduce the amount of opioids, alleviate postoperative pain, but also maintain the normal immune function of patients,which is worthy of recommendation.
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