Effect of Atorvastatin combined with Ginkgo Biloba extract on cognitive function and serum uncoupling protein 2 and brain-derived neurotrophic factor levels in patients with intracranial artery stenosis
WANG Li
The Second Department of Neurology, the No.2 Hospital of Baoding, Hebei Province, Baoding 071000, China
Abstract： Objective To explore the application value of Atorvastatin combined with Ginkgo Biloba extract in patients with intracranial artery stenosis. Methods A total of 112 patients with intracranial artery stenosis admitted to the Second Hospital of Baoding City from March 2019 to March 2021 were divided into the control group and the study group by random number table method, with 56 cases in each group. Patients in the control group were treated with Atorvastatin, and patients in the study group were treated with Atorvastatin and Ginkgo Biloba extract, both of which were treated continuously for three months. The cognitive function, activities of daily living, serum uncoupling protein 2(UCP2), brain-derived neurotrophic factor (BDNF), blood lipid levels and adverse reactions were compared between the two groups. Results Before treatment, there were no the statistically significant differences in scores of the mini mental state examination scale (MMSE), the activity of daily living ability scale (ADL), levels of UCP2, BDNF, total cholesterol(TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)between the two groups (P＞0.05).After treatment,MMSE,ADL scores and UCP2,BDNF,HDL-C levels of the study group were higher than those in the control group, the levels of TC, TG and LDL-C of the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Atorvastatin combined with Ginkgo Biloba extract can improve blood lipids, serum UCP2 and BDNF levels in patients with intracranial artery stenosis, and promote the recovery of cognitive function and activities of daily living, which is safe and reliable.
王 丽. 阿托伐他汀联合银杏叶提取物对颅内动脉狭窄患者认知功能及血清解偶联蛋白2、脑源性神经营养因子水平的影响[J]. 中国当代医药, 2022, 29(4): 100-103.
WANG Li. Effect of Atorvastatin combined with Ginkgo Biloba extract on cognitive function and serum uncoupling protein 2 and brain-derived neurotrophic factor levels in patients with intracranial artery stenosis. 中国当代医药, 2022, 29(4): 100-103.
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