Abstract：Objective To investigate the clinical effect of coagulation disorder on the prognosis of acute closed craniocerebral trauma. Methods The clinical data of 80 patients with acute closed craniocerebral trauma admitted to the Neurosurgery Department of Ruijin People's Hospital from January to December 2019 were retrospectively analyzed.According to whether the patients had coagulation disorder, they were divided into control group (40 cases, with normal coagulation function) and observation group (40 cases, with coagulation dysfunction). Glasgow coma index (GCS) score,activated partial thrombin time (APTT), prothrombin time (PT), fibrinogen (Fg), thrombin time (TT), incidence of progressive intracranial hemorrhage and good prognosis were compared between the two groups. Results After operation,TT and APTT in observation group were longer than those of control group, Fg was lower than that of control group, the differences were statistically significant (P＜0.05). PT in two groups was not statistically significant (P＞0.05). The good prognosis rate and GCS score of the observation group were lower than those of the control group, and the incidence of progressive intracranial hemorrhage was higher than that of the control group, with statistical significances (P＜0.05).Conclusion Acute closed craniocerebral trauma may promote the occurrence of coagulopathy in patients, and the more severe the coagulopathy dysfunction is, the worse the prognosis of patients, and the prognosis of patients can be evaluated according to the coagulation disorder.
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