Study on factors affecting the prognosis of patients with community-acquired pneumonia complicated with respiratory failure treated by nasal high-flow oxygen therapy
XIE Huawen LI Zhuoji LIN Guihua CHEN Jun ZHENG Yinbi
Department of Critical Care Medicine, the Second Affiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang 524000, China
Abstract:Objective To investigate the factors affecting the prognosis of patients with community-acquired pneumonia(CAP) combined with respiratory failure (RF) treated with nasal high-flow oxygen therapy (HFNC). Methods The clinical data of 80 patients with CAP and RF who received HFNC in the Second Affiliated Hospital of Guangdong Medical University from April 2017 to April 2020 were retrospectively analyzed. They were divided into HFNC failure group (18 cases) and the HFNC success group (62 cases) according to whether the patients needed invasive mechanical ventilation. The factors affecting the prognosis of HFNC treatment of patients with CAP and RF was analyzed. Results The oxygenation index, respiratory frequency, lung infection severity score (CURB-65 score), respiratory and circulatory support (SMART-COP) score, and acute physiology and chronic health score (APACHEⅡ) score in the HFNC failure group were compared with those in HFNC success group, the differences were statistically significant (P<0.05). Logistic regression analysis showed that oxygenation index ≤200 mmHg (β=1.311, OR=3.709, 95%CI=1.192-11.543), respiratory frequency ≥30 times/min (β=2.362, OR=10.607, 95%CI=3.182-35.354), CURB-65 score ≥3 points (β=1.291, OR=3.636, 95%CI=1.199-11.029), SMART-COP score ≥5 points (β=1.879, OR=6.548, 95%CI=2.098-20.431), APACHEⅡscore ≥20 points (β=1.197, OR=3.309, 95%CI=1.119-9.785) were high-risk factors for the prognosis of patients with CAP and RF treated with HFNC (P<0.05). Conclusion In order to achieve a good prognosis in the treatment of CAP patients with RF by HFNC, the influencing factors should be paid attention to in the clinical treatment process and timely intervention measures should be taken.