血管内皮生长因子基因rs699947位点多态性与汉族女性乳腺癌易感性的相关性

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摘要目的探讨血管内皮生长因子（VEGF）基因rs699947 位点多态性与汉族女性乳腺癌易感性的相关性。方法选取2013年3月至2018年8月黑龙江省齐齐哈尔和大庆地区的258 例乳腺癌患者作为乳腺癌组，选取同期162 例健康女性作为对照组。采用PCR 技术对外周血细胞进行基因分型。结果两组的等位基因和基因型分布比较，差异有统计学意义（P＜0.05）。校正混杂因素后，基因型AC 和AA 对乳腺癌的风险预测值分别为0.341 和0.170（P＜0.05）。显性模型和隐性模型下对乳腺癌的风险预测值分别为0.276 和2.657（P＜0.05）。结论 VEGF 基因rs699947 位点多态性与乳腺癌易感性存在明显关联，基因型AC 和AA 是乳腺癌发病的保护因素。

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	夏广韬
	俞洁
	刘宇飞
	郑立红
	裴耘婕
	张龙
	隋茹
	张明龙

关键词 ：乳腺癌, 血管内皮生长因子, 单核苷酸多态性, 保护因素

Abstract：Objective To investigate the correlation between rs699947 polymorphism of vascular endothelial growth factor (VEGF) gene and susceptibility to breast cancer in Han women. Methods From March 2013 to August 2018, 258 breast cancer patients in Qiqihar and Daqing of Heilongjiang Province were selected as the breast cancer group, and 162 healthy women were selected as the control group during the same period. PCR was used for genotyping of peripheral blood cells. Results The distribution of alleles and genotypes between the two groups was statistically significant(P＜0.05). After adjusting for confounding factors, the predictive value of AC and AA for breast cancer risk was 0.341 and 0.170, respectively (P＜0.05). The predictive risk of breast cancer in the dominant model and the recessive model were 0.276 and 2.657, respectively (P＜0.05). Conclusion The polymorphism of rs699947 in VEGF gene is significantly associated with breast cancer susceptibility. Genotype AC and AA are the protective factors of breast cancer.

Key words： Breast cancer Vascular endothelial growth factor Single nucleotide polymorphism Protective factor

基金资助:黑龙江省大学生创新创业训练计划项目（20201123 0037）；黑龙江省齐齐哈尔医学科学院项目（QMSI2019Z-07）。

引用本文:

夏广韬；俞洁；刘宇飞；郑立红；裴耘婕；张龙；隋茹；张明龙. 血管内皮生长因子基因rs699947位点多态性与汉族女性乳腺癌易感性的相关性[J]. 中国当代医药, 2022, 29(4): 20-23.
XIA Guangtao；YU Jie；LIU Yufei；ZHENG Lihong；PEI Yunjie；ZHANG Long；SUI Ru；ZHANG Minglong. Correlation between rs699947 polymorphism of vascular endothelial growth factor gene and susceptibility to breast cancer in Han women. 中国当代医药, 2022, 29(4): 20-23.

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[1]	Akram M，Iqbal M，Daniyal M，et al.Awareness and current knowledge of breast cancer[J].Biol Res，2017，50（1）：33.
[2]	Tang J，Kong D，Cui Q，et al.Prognostic Genes of Breast Cancer Identified by Gene Co-expression Network Analysis[J].Front Oncol，2018，8：374.
[4]	Apte RS，Chen DS，Ferrara N.VEGF in Signaling and Disease：Beyond Discovery and Development[J].Cell，2019，176（6）：1248-1264.
[13]	黄清南，黄耀，李明，等.血管内皮生长因子（VEGF）高表达和血小板应答蛋白1（TSP-1）低表达与乳腺癌患者预后相关分析[J].细胞与分子免疫学杂志，2019，35（9）：828-831.
[3]	Gao C，Zhuang J，Zhou C，et al.SNP mutation-related genes in breast cancer for monitoring and prognosis of patients：A study based on the TCGA database[J].Cancer Med，2019，8（5）：2303-2312.
[5]	Fujii T，Hirakata T，Kurozumi S，et al.VEGF-A Is Associated With the Degree of TILs and PD-L1 Expression in Primary Breast Cancer[J].In Vivo，2020，34（5）：2641-2646.
[6]	Song Y，Hu J，Chen Q，et al.Association between vascular endothelial growth factor rs699947 polymorphism and the risk of three major urologic neoplasms（bladder cancer，prostate cancer，and renal cell carcinoma）：A meta-analysis involving 11 204 subjects[J].Gene，2018，30（679）：241-252.
[7]	Zhao HL，Yu JH，Huang LS，et al.Relationship between vascular endothelial growth factor-2578C＞a gene polymorphism and lung cancer risk：a meta-analysis[J].BMC Med Genet，2020，21（1）：17.
[8]	Quan Y，Yang J，Qin T，et al.Associations between twelve common gene polymorphisms and susceptibility to hepatocellular carcinoma：evidence from a meta-analysis[J].World J Surg Oncol，2019，17（1）：216.
[9]	Sta A，Mje B，Zmaj C.The association of vascular endothelial growth factor polymorphism （rs699947）with diabetic foot ulcer and oxidative status[J].Gene Reports，2020，19：100 606.
[10]	Siveen KS，Prabhu K，Krishnankutty R，et al.Vascular Endothelial Growth Factor （VEGF）Signaling in Tumour Vascularization：Potential and Challenges[J].Curr Vasc Pharmacol，2017，15（4）：339-351.
[11]	Cierna Z，Smolkova B，Cholujova D，et al.Decreased levels of circulating cytokines VEGF，TNF-β and IL-15 indicate PD-L1 overexpression in tumors of primary breast cancer patients[J].Sci Rep，2021，11（1）：1294.
[12]	Jiang W，Li Y，Ou J，et al.Expression analysis of E-cad and vascular endothelial growth factor in triple-negative breast cancer patients of different ethnic groups in western China[J].Medicine （Baltimore），2017，96（42）：e8155.
[14]	Kiso M，Tanaka S，Saji S，et al.Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network[J].Int J Cancer，2018，143（11）：2905-2918.
[15]	Rahoui J，Laraqui A，Sbitti Y，et al.Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer：a Moroccan case-control study[J].Medical Oncology，2014，31（9）：193.
[16]	Jacobs EJ，Feigelson HS，Bain EB，et al.Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study Ⅱcohort[J].Breast Cancer Res，2006，8（2）：R22.
[17]	Kapahi R，Guleria K，Sambyal V，et al.Association of VEGF and VEGFR1 polymorphisms with breast cancer risk in North Indians[J].Tumour Biol，2015，36（6）：4223-4234.
[18]	Rezaei M，Hashemi M，Sanaei S，et al.Association Between Vascular Endothelial Growth Factor Gene Polymorphisms with Breast Cancer Risk in an Iranian Population[J].Breast Cancer （Auckl），2016，10：85-91.
[19]	Albalawi IA，Mir R，Abu Duhier FM.Genetic Effects of Vascular Endothelial Growth Factor A （VEGF-A） and Its Association with Disease Progression in Breast Cancer Population of Saudi Arabia[J].Asian Pac J Cancer Prev，2020，21（1）：139-145.
[20]	Sa A，As B，Sma A，et al.Association analysis of the VEGF gene variants with breast cancer susceptibility and tumor characteristics in an indigenous population：A pilot study[J].Gene Reports，2019，16：100 447.
[21]	Madrid-Paredes A，Casado-Combreras Má，Pérez-Ramírez C，et al.Association of ABCB1 and VEGFA gene polymorphisms with breast cancer susceptibility and prognosis[J].Pathol Res Pract，2020，216（4）：152 860.