慢性阻塞性肺疾病稳定期患者的分组营养状况分析

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摘要目的探讨慢性阻塞性肺疾病稳定期患者经慢性阻塞性肺疾病（COPD）全球倡议指南（GOLD）分组的各组人群营养指标的差异。方法选取2018年1月至2020年12月在江西省人民医院门诊就诊及住院的160 例稳定期COPD 患者作为研究对象，按照COPD 稳定期患者依据GOLD 指南分为A、B、C、D 组，每组各40例。另选同期40 例健康成年人为对照组。比较五组的血清中总蛋白（TP）、白蛋白、肌酐（Cre）、尿素氮（BUN）指标。结果 A、B、C、D 组COPD 稳定期患者的血清中的TP、白蛋白均低于健康对照组，Cre 水平均高于健康对照组，差异有统计学意义（P＜0.05）。A、B、C、D 组和对照组血清BUN 水平比较，差异无统计学意义（P＞0.05）。A、B、C、D 组的血清TP、Cre、BUN 比较，差异无统计学意义（P＞0.05），A、B、C 组白蛋白比较，差异无统计学意义（P＞0.05）。D 组的血清白蛋白水平低于A、B、C 组，差异有统计学意义（P＜0.05）。结论血清白蛋白水平可作为COPD 稳定期患者预估未来急性加重风险高及症状重的重要指标，临床需要高度警惕，适时干预治疗，可能减少急性加重，改善患者临床症状。

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	喻杰
	罗琳琳
	黎云霞
	郭猷殚

关键词 ：慢性阻塞性肺疾病, 营养状况, 血清总蛋白, 白蛋白, 肌酐, 尿素氮

Abstract：Objective Discussion on the difference in nutrition indicators of various groups of chronic obstructive pulmonary disease (COPD) Global Initiative guidelines (GOLD) in patients with COPD in stable stage.Methods From January 2018 to December 2020,160 stable COPD patients who were in the Department of Outpatient of Jiangxi Provincial People′s Hospital were selected as subjects.According to GOLD guidelines,stable COPD patients were divided into groups A,B,C and D,with 40 cases in each group.Forty healthy adults at the same time were selected as control group.The serum total protein (TP),albumin,creatinine (Cre) and urea nitrogen (BUN) in five groups were compared.Results The serum TP and albumin in COPD stable stage patients in groups A,B,C and D were lower than those in healthy control group,and Cre levels were higher than those in healthy control group,the differences were statistically significant (P＜0.05).There was no significant difference in serum BUN level between groups A,B,C and D and control group (P＞0.05).There were no statistical significance in serum TP,Cre and BUN in groups A,B,C and D(P＞0.05),and there were no statistical significance in serum albumin in groups A,B and C (P＞0.05).The serum albumin level in group D was lower than that in groups A,B and C,and the difference was statistically significant (P＜0.05).Conclusion Serum albumin can be used as an important indicator of the stable stage of COPD patients with high risk of acute exacerbation and severity symptoms in the future,and needs high vigilance in clinic practice,timely intervention treatment may reduce acute exacerbation,improve the clinical symptoms of patients.

Key words： Chronic obstructive pulmonary disease Nutritional status；Serum total protein Albumin Creatinine Blood urea nitrogen

基金资助:江西省卫生计生委科技计划项目（20195007）

引用本文:

喻杰；罗琳琳；黎云霞；郭猷殚. 慢性阻塞性肺疾病稳定期患者的分组营养状况分析[J]. 中国当代医药, 2022, 29(3): 40-43.
YU Jie ；LUO Linlin； LI Yunxia ；GUO Youdan. Analysis ofnutritional status in different group patients with chronic obstructive pulmonary disease in stable stage. 中国当代医药, 2022, 29(3): 40-43.

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