Objective To explore the application effect of focus cycle management method (FOCUS-PDCA)in multi-link quality control of pharmacy intravenous admixture service.Methods The occurrence of various errors in Pharmacy Intravenous Admixture Service of East Branch of Zibo Central Hospital during 2016-2022 was tracked.FOCUS-PDCA was used to find the problems,analyze the causes,formulate corresponding goals and measures and make continuous improvement.Mmedication advices before the implementation of FOCUS-PDCA in 2016 were set as the control group,medication advices after the implementation of FOCUS-PDCA from 2017 to 2019 were set as the first round intervention group,medication advices after the implementation of FOCUS-PDCA from 2020 to 2022 were set as the second round intervention group,the change of the rate of unreasonable doctor's advices not reviewed,drug dispensing,labeling,mixing and rechecking packaging unqualified rates before and after the two intervention rounds were analyzed.Results The unqualified rates of drug dispensing,labeling and mixing in the first round intervention group were lower than those in the control group,the differences were statistically significant (P＜0.017).There were no significant differences between the first round intervention group and the control group in rate of unreasonable doctor's advices not reviewed and rechecking packaging unqualified rate (P＞0.05).The unqualified rates of all kinds of quality in the second round intervention group were lower than those of control group,and the differences were statistically significant (P＜0.017).The rate of unreasonable doctor's advices not reviewed,drug dispensing and rechecking packaging unqualified rates of the second round intervention group were lower than those of the first round intervention group,and the differences were statistically significant (P＜0.017).There was no significant difference in the unqualified rate of labeling and mixing in the second round intervention group compared with the first round intervention group(P＞0.05).Conclusion FOCUS-PDCA can significantly reduce the error rate of pharmacy intravenous admixture service and provide guarantee for clinical rational drug use.