Objective To investigate the effect of precision anesthesia intervention in non-cardiac surgery perioperative period in high-risk cardiovascular patients.Methods A total of 190 high-risk cardiovascular patients admitted to the First People's Hospital of Guangyuan from January to December 2022 were selected as research objects,and they were divided into observation group(95 cases)and control group(95 cases)according to random number table method.The control group was administered with general experience management,and the observation group was administered with precision anesthesia intervention measures.Serological indexes and incidence of cardiac adverse events were compared between the two groups.Results Cardiac troponin(cTn),creatine kinase isoenzyme(CK-MB),myoglobin(Mb),high sensitivity troponin T(hs-TnT),brain natriuretic peptide(BNP),N terminal pro B type natriuretic peptide(NT-proBNP)and C-reactive protein(CRP)in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total incidence of cardiac adverse events in observation group was lower than that in control group,and the difference was statistically significant (P＜0.05).Conclusion Precision anesthesia intervention in high-risk cardiovascular patients during non-cardiac surgery perioperative period can further reduce cardiac injury and reduce the incidence of adverse events,which is worthy of clinical application.