中国当代医药
中国当代医药杂志欢迎您 今天是   2025年4月5日星期六
设为首页  加入收藏  联系我们         
 
      首 页    |    本刊简介     |    期刊荣誉     |    编采团队     |    会务培训     |    理事单位     |    下载专区     |    在线留言     |    联系我们     |     返回中国当代医药网
中国当代医药
  妇幼医学 本期目录 | 过刊浏览 | 高级检索 |
血清晚期氧化蛋白产物与单核细胞趋化蛋白-1水平对妊娠糖尿病孕妇子痫前期发生的诊断价值
许丽湖 潘月琼 杨淑静 谭佳昕 陈关凤▲
 
广西医科大学附属民族医院产科,广西南宁 530001
Diagnostic value of serum advanced oxidized protein products and monocyte chemoattractant protein-1 levels in the occurrence of preeclampsia in pregnant women with gestational diabetes mellitus
XU Lihu PAN Yueqiong YANG Shujing TAN Jiaxin CHEN Guanfeng▲#br#
Department of Obstetrics,Affiliated Hospital for Nationalities,Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning 530001,China
全文: PDF (800 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 
目的 探究血清晚期氧化蛋白产物(AOPP)、单核细胞趋化蛋白-1(MCP-1)水平与妊娠期糖尿病(GDM)孕妇子痫前期(PE)发生的相关性。方法 选取2021 年10 月至2023 年9 月广西医科大学附属民族医院产科收治的70 例GDM 并发PE 孕妇作为合并组,另选取同期来广西医科大学附属民族医院孕检的单纯GDM 孕妇70 例作为非合并组,统计分析两组研究对象的临床资料及实验室指标,采用多因素logistic 分析血清AOPP、MCP-1 与GDM 并发PE 的相关性。选用ROC 曲线分析血清AOPP、MCP-1 联合检测GDM 并发PE 的诊断价值。结果 单因素分析结果显示,两组患者在年龄、孕前体重指数(BMI)、血清AOPP 以及MCP-1 表达水平上的比较,差异均具有统计学意义(P<0.05);多因素logistic 回归显示,年龄、孕前BMI、血清AOPP 以及MCP-1 均为GDM 并发PE的独立危险因素(P<0.05)。ROC 曲线显示,血清AOPP、MCP-1 及二者联合检测曲线下面积为0.867、0.916、0.942。结论 AOPP、MCP-1 与GDM 并发PE 发病风险密切相关,对病情诊断具有较高应用价值。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
关键词 血清晚期氧化蛋白产物单核细胞趋化蛋白-1妊娠糖尿病子痫前期    
Abstract
Objective To explore the correlation between serum levels of late oxidized protein product (AOPP),monocyte chemoattractant protein-1 (MCP-1)and preeclampsia (PE)in pregnant women with gestational diabetes mellitus(GDM).Methods A total of 70 pregnant women with GDM complicated with PE admitted to the obstetrics Department of the Affiliated Hospital for Nationalities of Guangxi Medical University from October 2021 to September 2023 were selected as the combination group,and another 70 pregnant women with simple GDM who came to the Affiliated Hospital for Nationalities,Guangxi Medical University during the same period were selected as the non-combination group.The clinical data and laboratory indicators of the two groups of subjects were statistically analyzed.Multivariate logistic analysis was used to analyze the correlation between AOPP,MCP-1 and GDM complicated with PE.ROC was used to analyze the diagnostic value of serum AOPP and MCP-1 combined detection of GDM complicated with PE.Results Univariate analysis showed that there were statistically significant differences in age,pre-pregnancy body mass index(BMI),serum AOPP and MCP-1 expression levels between the two groups(P<0.05).Multivariate logistic regression showed that age,pre-pregnancy BMI,serum AOPP and MCP-1 were independent risk factors for GDM complicated with PE(P<0.05).ROC curve showed that the areas under serum AOPP,MCP-1 and their combined detection curves were 0.867,0.916 and 0.942.Conclusion AOPP and MCP-1 are closely related to the risk of GDM with PE,and have high application value in the diagnosis of the disease.
Key wordsSerum late oxidized protein products    Monocyte chemotactic protein-1    Gestational diabetes mellitus    Preeclampsia
    
基金资助:广西壮族自治区卫生健康委员会自筹经费科研课题(Z20211379)
引用本文:   
许丽湖;潘月琼;杨淑静;谭佳昕;陈关凤. 血清晚期氧化蛋白产物与单核细胞趋化蛋白-1水平对妊娠糖尿病孕妇子痫前期发生的诊断价值[J]. 中国当代医药, 2024, 31(14): 41-44.
XU Lihu PAN Yueqiong YANG Shujing TAN Jiaxin CHEN Guanfeng▲. Diagnostic value of serum advanced oxidized protein products and monocyte chemoattractant protein-1 levels in the occurrence of preeclampsia in pregnant women with gestational diabetes mellitus. 中国当代医药, 2024, 31(14): 41-44.
链接本文:  
https://www.dangdaiyiyao.com/CN/     或     https://www.dangdaiyiyao.com/CN/Y2024/V31/I14/41
中华人民共和国互联网药品信息服务资格证书(京)-非经营性-2016-0092
京ICP备11001767号-6  京公网安备 11010502046607号  互联网药品信息服务资格证  期刊出版许可证  广告经营许可证
信息产业部备案管理系统网址 http://beian.miit.gov.cn/state/outPortal/loginPortal.action
投稿热线:010-59626690 总机:010-59626692/18/19/20   传真:010-59626204   投稿信箱:ddyy@vip.163.com
地址:北京市朝阳区东四环中路78号楼(大成国际中心B1座)8B02室   邮编:100124
技术支持:北京玛格泰克科技发展有限公司
Copyright 2000-2014 版权所有 《中国当代医药》杂志社 未经授权请勿转载