Objective To analyze the influence of wechat platform combined with case-based learning (CBL)teaching on students'clinical thinking ability in medical oncology nursing teaching.Methods Thirty-three cases of nursing students who were practiced in the Department of Medical Oncology,Shandong Affiliated Hospital of Weifang Medical University from January 2022 to June 2022 were selected as the control group,and routine teaching was carried out.Thirty-three cases of nursing students who were practiced in the Department of Medical Oncology,Shandong Affiliated Hospital of Weifang Medical University from July 2022 to January 2023 were selected as the observation group,and wechat platform combined with case-based learning(CBL)teaching was given.The clinical thinking ability and comprehensive quality ability of nursing students in the two groups were compared.Results After teaching,the assessment scores of theoretical knowledge and practical skills of nursing students in the observation group were higher than the control group,and the differences were statistically significant (P＜0.05).The scores of clinical thinking ability in the two groups were higher than those in the control group,and the scores of clinical thinking ability and the comprehensive quality and ability assessment form for clinical practice of nursing students after the teaching were higher than the control group,and the differences were statistically significant (P＜0.05).Conclusion The application of wechat platform combined with CBL teaching in the teaching of medical oncology nursing can achieve remarkable results,which can not only improve the graduation results of nursing students,but also enhance their clinical thinking ability and comprehensive quality ability.