Objective To investigate the effect of moxibustion combined with Irbesartan Tablets on diabetic nephropathy(DKD)patients in stage Ⅲand Ⅳ.Methods A total of 80 DKD patients treated in Jiujiang Hospital of Traditional Chinese Medicine from August 2020 to August 2021 were selected as the study objects,and were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with basic treatment and oral Irbesartan Tablets,and the observation group was added with moxibustion.The clinical efficacy,traditional Chinese medicine syndrome score,blood glucose level,inflammatory factor level,biochemical indexes and adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The traditional Chinese medicine syndrome scores of the observation group after treatment were lower than those of the control group,and the differences were statistically significant(P＜0.05).In terms of blood glucose,fasting blood glucose(FPG)and 2 h postprandial blood glucose(2 hPG)were lower than those in control group,with statistical significances (P＜0.05).In terms of inflammatory factors,the levels of tumor necrosis factor α (TNF-α),hypersensitive C-reactive protein (hs-CRP)and interleukin-6 (IL-6)were lower than those of control group,with statistical significances (P＜0.05).In terms of biochemical indexes,the levels of urea nitrogen (BUN),blood creatinine (Scr),24 h urinary protein quantity (mALB),urinary microalbumin (MAU),urinary albumin/creatinine ratio(ACR)and urinary retinol binding protein(RBP)were lower than those of control group,and the differences were statistically significants (P＜0.05).No obvious adverse reactions were observed in the two groups.Conclusion The application of moxibustion combined with Irbesartan Tablets in the treatment of patients with DKD Ⅲand Ⅳcan improve blood glucose level and renal function,relieve clinical symptoms,reduce inflammatory reaction,with exact effect and good safety,which is worthy of promotion.