淀粉样脑血管病相关心脏损伤的研究进展

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摘要淀粉样脑血管病是在世界范围内普遍存在的一种疾病，在老年人阿尔茨海默病患者中更为常见，最终结果就是导致大脑多发微出血灶。其特征是淀粉样蛋白-β 在大脑皮质和软脑膜血管壁沉积，可能通过激活星形胶质细胞、小胶质细胞和促炎症物质来诱导大脑慢性炎症状态，损伤血脑屏障的完整性。淀粉样脑血管病是老年人认知改变和脑内出血的主要原因，患者也经常伴有心脏损伤。淀粉样脑血管病造成的心脏损伤是一个新的研究领域，需要深入分析从而提供治疗及预防靶点。

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关键词 ：淀粉样脑血管病, 淀粉样蛋白-&beta, Tau 蛋白, 转甲状腺素淀粉样蛋白, 心脏损伤

Abstract：Cerebral amyloid angiopathy is a prevalent disease in the world,more common in elderly patients with Alzheimer's disease,and the end result is multiple microbleeding foci in the brain.It is characterized by the deposition of amyloid-β in the cerebral cortex and leptomeningeal blood vessel wall,which may induce the chronic inflammatory state of the brain and damage the integrity of the blood brain barrier by activating astrocytes,microglia,and pro-inflammatory substances.Cerebral amyloid angiopathy is the main cause of cognitive changes and intracerebral hemorrhage in the elderly,and patients are often associated with cardiac damage.Cardiac damage caused by cerebral amyloid angiopathy is a new area of research that requires in-depth analysis to provide therapeutic and preventive targets.

Key words： Amyloid cerebrovascular disease Amyloid-&beta Tau protein Transthyroxine amyloid Cardiac damage

引用本文:

吕汶彩；欧阳升▲；李江娇；张志江. 淀粉样脑血管病相关心脏损伤的研究进展[J]. 中国当代医药, 2024, 31(11): 191-194.
LYU Wencai OUYANG Sheng▲ LI Jiangjiao ZHANG Zhijiang. Research progress in cardiac injury associated with cerebral amyloid angiopathy. 中国当代医药, 2024, 31(11): 191-194.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2024/V31/I11/191

[1]	Parodi-Rullán RM，Javadov S，Fossati S.Dissecting the Crosstalk between Endothelial Mitochondrial Damage，Vascular Inflammation，and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer's Disease[J].Cells，2021，10（11）：2903.
[2]	Bonaterra-Pastra A，Benítez S，Pancorbo O，et al.Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloidangiopathy[J].FrontAgingNeurosci，2023，15：1134399.
[3]	Swarup O，Barker JL，Watson R，et al.Cerebral amyloid angiopathy：clinical presentations and management challenges in the Australian context[J].Internal medicine journal，2023，53（6）：907-916.
[4]	Hernandez-Guillamon M.Implications of a pathophysiological framework for cerebral amyloid angiopathy[J].Lancet Neurol，2023，22（7）：550-551.
[5]	Meng XM，Yuan JH，Zhou ZF，et al.Evaluation of time-dependent phenotypes of myocardial ischemia-reperfusion in mice[J].Aging，2023，15：10627-10639.
[6]	刘刚.淀粉样脑血管病与脑血管炎性反应的相关性及临床意义[J].中国医药指南，2017，15（32）：97-98.
[7]	Smith MA，Feinglass NG.Perioperative implications of amyloidosis and amyloid cardiomyopathy：A review for anesthesiologists[J].J Clin Anesth，2023，92：111271.
[8]	李晓秋，苏东风，王耀山，等.淀粉样脑血管病患者的脑血管炎症反应及其临床特点[J].临床神经病学杂志，2013，26（2）：90-93.
[9]	Elia A，Parodi-Rullan R，Vazquez-Torres R，et al.Amyloid β induces cardiac dysfunction and neuro-signaling impairment in the heart of an Alzheimer's disease model[J].bioRxiv，2023：548558.
[10]	Lui F，Alcaide J，Knowlton S，et al.Pathogenesis of cerebral amyloid angiopathy caused by chaotic glymphatics-Minireview[J].Front Neurosci，2023，17：1180237.
[11]	De Souza A，Tasker K.Inflammatory Cerebral Amyloid Angiopathy：A Broad Clinical Spectrum[J].J Clin Neurol，2023，19（3）：230-241.
[12]	Situ M，Citalan-Madrid AF，Stamatovic SM，et al.Transcriptomic Profile of Blood-Brain Barrier Remodeling in Cerebral Amyloid Angiopathy[J].Front Cell Neurosci，2022，16：931247.
[13]	朱明伟，王鲁宁.脑老化及相关神经疾病新进展[J].中国现代神经疾病杂志，2014，14（3）：161-169.
[14]	Stakos DA，Stamatelopoulos K，Bampatsias D，et al.The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease：JACC Focus Seminar[J].J Am Coll Cardiol，2020，75（8）：952-967.
[15]	Xu XF，Xu HK，Zhang ZC.Cerebral amyloid angiopathy-related cardiac injury：Focus on cardiac cell death[J].Front Cell Dev Biol，2023，11：1156970.
[16]	Gagno G，Ferro F，Fluca AL，et al.From Brain to Heart：Possible Role of Amyloid-β in Ischemic Heart Disease and Ischemia-Reperfusion Injury[J].Int J Mol Sci，2020，21（24）：9655.
[17]	Jang S，Chorna N，Rodríguez-Graciani KM，et al.The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells[J].J Alzheimers Dis，2023，93（1）：307-319.
[18]	Takaichi Y，Chambers JK，Takahashi K，et al.Amyloid β and tau pathology in brains of aged pinniped species（sea lion，seal，and walrus）[J].Acta Neuropathol Commun，2021，9（1）：10.
[19]	Tayler HM，MacLachlan R，Güzel O，et al.Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage[J].Brain Commun，2023，5（2）：d112.
[20]	Rabin JS，Nichols E，LaJoie R，et al.Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline[J].Brain，2022，145（8）：2823-2833.
[21]	Cisternas P，Taylor X，Lasagna-Reeves CA.The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy[J].Int J Mol Sci，2019，20（24）：6319.
[22]	García-Escobar A，Vera-Vera S，Tébar-Márquez D，et al.Neutrophil-to-lymphocyte ratio an inflammatory biomarker，and prognostic marker in heart failure，cardiovascular disease and chronic inflammatory diseases：New insights for a potential predictor of anti-cytokine therapy responsiveness[J].Microvasc Res，2023，150：104598.
[23]	Li SD，Wang LH，Wang JY，et al.Inhibition of AGEs -RAGE-PP2A Axis Alleviates Cognitive Impairment after Chronic Heart Failure[J].Cell Mol Biol（Noisy-le-grand），2023，69（5）：179-185.
[24]	Flavin WP，Hosseini H，Ruberti JW，et al.Traumatic brain injury and the pathways to cerebral tau accumulation[J].Front Neurol，2023，14：1239653.
[25]	Chen W，Jin FZ，Cao GH，et al.ApoE4 May be a Promising Target for Treatment of Coronary Heart Disease and Alzheimer's Disease[J].Curr Drug Targets，2018，19（9）：1038-1044.
[26]	Yamada M，Naiki H.Cerebral amyloid angiopathy[J].Prog Mol Biol Transl Sci，2012，107：41-78.
[27]	Yamada M.Cerebral amyloid angiopathy：an overview [J].Neuropathology，2000，20（1）：8-22.
[28]	Sakashita N，Ando Y，Jinnouchi K，et al.Familial amyloidotic polyneuropathy（ATTR Val30Met）with widespread cerebral amyloid angiopathy and lethal cerebral hemorrhage[J].Pathol Int，2001，51（6）：476-480.
[29]	Hamasaki H，Shijo M，Nakamura A，et al.Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults：The Hisayama study[J].Brain Pathol，2022，32（1）：e13014.
[30]	Sumi-Akamaru H，Eto M，Yamauchi A，et al.Evidence that glial cells attenuate G47R transthyretin accumulation in the central nervous system[J].Neuropathology，2018，38（1）：11-21.
[31]	张昕彤，任卫东，张晶，等.心脏淀粉样变的研究进展[J].中国医科大学学报，2019，48（11）：1029-1032.