Effect of rapid initiation of highly active antiretroviral therapy on treatment compliance and prognosis of human immunodeficiency virus infected acquired immune deficiecy syndrome patients with high CD4+T lymphocytes
ZHOU Min KUANG Lingzhi LIU Min
Department of Infectious Diseases, Jiangxi Xinyu People's Hospital, Jiangxi Province, Xinyu 338000, China
Abstract：Objective To investigate the effect of rapid initiation of highly active antiretroviral therapy (HAART) on the treatment compliance and prognosis of human immunodeficiency virus infected acquired immune deficiecy syndrome (HIVAIDS) patients with high CD4+T lymphocytes. Methods From July to December 2021, 61 HIVAIDS patients hospitalized in Department of Infectious Diseases, Jiangxi Xinyu People's Hospital were selected. 32 patients who went to the hospital in time within 7 days after diagnosis and started antiviral treatment with informed consent were set as the fast start group. 29 patients who did not go to the AIDS clinic in time after diagnosis or did not receive the fast start HAART after transfer were set as the fast start group. The baseline viral load (HIV-RNA) and CD4+T lymphocyte count of two groups of patients, as well as the viral load and CD4+T lymphocyte count were recorded after 6 and 12 months of antiviral treatment, and the treatment compliance, virus inhibition rate, and follow-up loss rate of the enrolled patients were recorded. Results The the CD4+T lymphocyte count in the rapid start group was higher than that in the non rapid start group at 6 and 12 months of treatment, with statistically significant difference (P＜0.05). After 6 and 12 months of treatment, the HIV-RNA level of the two group was lower than before treatment, while the HIV-RNA level in the rapid start group was lower than those in the non rapid start group at 6 and 12 months of treatment, with astatistically significant difference (P＜0.05). The treatment compliance of the rapid start group was 100.00% (32/32), and the virus inhibition rate was 93.75% (30/32), which were higher than 82.76% (24/29) and 68.97% (20/29) of the non rapid start group, the differences were statistically significant (P＜0.05). The loss of follow-up rate was 0, which was lower than 17.24% (5/29) of the non rapid start group, the difference was statistically significant (P＜0.05). Conclusion Rapid initiation (within 7 days of diagnosis) of HAART can maximize the adherence of HIV/AIDS patients with high CD4+T lymphocytes to antiviral treatment, increase the virus inhibition rate, CD4+T lymphocyte count level, and reduce the loss of follow-up rate, which is worthy of clinical promotion.
周 敏 况玲芝 刘 敏. 快速启动高效抗反转录病毒治疗对较高CD4+T淋巴细胞的人类免疫缺陷病毒感染-艾滋病患者治疗依从性及预后的影响[J]. 中国当代医药, 2024, 31(1): 23-26.
ZHOU Min KUANG Lingzhi LIU Min. Effect of rapid initiation of highly active antiretroviral therapy on treatment compliance and prognosis of human immunodeficiency virus infected acquired immune deficiecy syndrome patients with high CD4+T lymphocytes. 中国当代医药, 2024, 31(1): 23-26.
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