Two cases of Chlamydia psittaci pneumonia and literature review
LI Heqiang1 PENG Xiu1 WANG Xiaohong2
1. School of Clinical Medicine, Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan 750004, China
2. Department of Intensive Care Medicine, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan 750004, China
Abstract：Two patients had a history of pigeon contact and presented with fever, fatigue and dyspnea. One patient developed acute respiratory distress syndrome (ARDS) on the fourth day of the disease and required non-invasive ventilator assisted ventilation. Leukocyte count was slightly increased in 2 patients, lymphocyte percentage was decreased, platelet count was normal, procalcitonin was increased, C-reactive protein was significantly increased, alanine aminotransferase and aspartate aminotransferase were increased to varying degrees, serum sodium, potassium and albumin were decreased, erythrocyte sedimentation rate (ESR) was normal in 1 patient and slightly increased in 1 patient. The pathogen could not be identified by routine culture and serological examination of blood and alveolar lavage fluid. Chest X-ray, computed tomography (CT) showed large exudation and consolidation of one lung lobe, rapid progression in severe cases, involving both lung lobes, respiratory failure, and poor effect of empirical antibiotic use. After timely application of metagenomic next-generation sequencing (mNGS) technology combined with avian contact history, the patient was finally diagnosed with Chlamydia psittaci pneumonia. After treatment with quinolones combined with tetracycline antibiotics, the symptoms, signs and imaging abnormalities of the patient were significantly improved, but 1 patient had poor imaging absorption and was further treated with macrolide antibiotics for 1 week. Follow-up examination of chest CT showed that the lesion was basically absorbed. By analyzing the clinical characteristics, diagnosis and treatment process of these two patients, it can provide reference for clinical diagnosis and treatment of these diseases.
李合强1 彭 秀1 王晓红2. 鹦鹉热衣原体肺炎病例报告2例及文献复习[J]. 中国当代医药, 2024, 31(1): 140-145.
LI Heqiang1 PENG Xiu1 WANG Xiaohong2. Two cases of Chlamydia psittaci pneumonia and literature review. 中国当代医药, 2024, 31(1): 140-145.
Hogerwerf L，Roof I，de Jong MJK，et al.Animal sources for zoonotic transmission of psittacosis：a systematic review[J].BMC Infect Dis，2020，20（1）：192.
[2]
Hogerwerf L，DE Gier B，Baan B，et al.Chlamydia psittaci （psittacosis） as a cause of community-acquired pneumonia：a systematic review and meta-analysis[J].Epidemiol Infect，2017， 145（15）：3096-3105.
[3]
Nieuwenhuizen AA，Dijkstra F，Notermans DW，et al.Laboratory methods for case finding in human psittacosis outbreaks：a systematic review[J].BMC Infect Dis，2018，18（1）：442.
[4]
Balsamo G，Maxted AM，Midla JW，et al.Compendium of Measures to Control Chlamydia psittaci Infection Among Humans （Psittacosis） and Pet Birds （Avian Chlamydiosis），2017[J].J Avian Med Surg，2017，31（3）：262-282.
Rane V，Khailin K，Williams J，et al.Underdiagnosis of Chlamydia trachomatis and Chlamydia psittaci revealed by introduction of respiratory multiplex PCR assay with Chlamydiaceae family primers[J].Diagn Microbiol Infect Dis，2018，90（3）：163-166.
Chen X，Cao K，Wei Y，et al.Metagenomic next-generation sequencing in the diagnosis of severe pneumonias caused by Chlamydia psittaci[J].Infection，2020，48（4）：535-542.
[15]
Sun W，Lu Z，Yan L.Clinical efficacy of metagenomic next- generation sequencing for rapid detection of Mycobacterium tuberculosis in smear-negative extrapulmonary specimens in a high tuberculosis burden area[J].Int J Infect Dis，2021， 103：91-96.
[16]
Miao Q，Ma Y，Wang Q，et al.Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice[J].Clin Infect Dis，2018， 67（suppl_2）：S231-S240.
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