Effect of Periplaneta Americana gel on preventing skin injury caused by radiation therapy
QUE Suyun1 YANG Tao2 MA Xuanlei1 CUN Yufang1 HE Jiangtao2 YANG Kun3
1.Department of Pharmacy,People's Hospital of Dali Prefecture,Yunnan Province,Dali 671400,China;
2.Department of Oncology,People's Hospital of Dali Prefecture,Yunnan Province,Dali 671400,China;
3.Department of Pharmacy,Maternity and Child Health Care of Zaozhuang,Shandong Province,Zaozhuang 277101,China
Abstract：Objective To investigate the effect of Periplaneta Americana gel on skin injury caused by radiation therapy.Methods From January 2021 to August 2022,110 patients with head and neck tumors and breast cancer treated by the first course radiotherapy in People's Hospital of Dali Prefecture were selected as the research objects.They were divided into drug group(55 cases)and blank control group(55 cases)by drawing lots.The drug group used Periplaneta Americana gel to smear on the skin in the radiation field,and the blank control group used blank gel to smear on the skin in the radiation field.The incidence of acute radiation dermatitis,the effective rate of acute radiation dermatitis,the degree of pain relief,the curative effect and adverse reactions of chronic radiation dermatitis were observed.Results The incidence of acute radiation dermatitis in the drug group was lower than that in the blank control group,and the difference was statistically significant(P＜0.05).The effective rate of the treatment of acute radiation dermatitis in the drug group was higher than that in the blank control group,and the difference was statistically significant(P＜0.05).The pain score of the drug group was lower than that of the blank control group,and the difference was statistically significant (P＜0.05).The incidence of chronic radiation dermatitis in the drug group was lower than that in the blank control group at 90 days after radiotherapy,and the difference was statistically significant (P＜0.05).Conclusion Periplaneta Americana gel has a good effect on the prevention and treatment of radiation dermatitis,can alleviate the pain of patients,and provide guarantee for the smooth treatment of radiotherapy patients.
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QUE Suyun1 YANG Tao2 MA Xuanlei1 CUN Yufang1 HE Jiangtao2 YANG Kun3. Effect of Periplaneta Americana gel on preventing skin injury caused by radiation therapy. 中国当代医药, 2023, 30(21): 18-22.
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