Abstract：Objective To investigate the clinical characteristics of patients with pancytopenia in the third-class comprehensive hospital preliminarily. Methods A total of 836 patients with pancytopenia in our hospital from January 2016 to October 2020 were selected as the subjects, and divided into hemotopathy group (287 cases) and non-hemotopathy group (488 cases). The blood cell reduction degree were compared between the two groups. The distribution and cause of all patients were analyzed and summarized. Results Among the 836 patients, the degree of pancytopenia was mainly mild or moderate.There were 785 cases(93.9%)of mild and moderate anemia,Pations of platelet count([75-<125]×109/L)was 21 cases(62.32%),WBC count([2.0-<3.5]×109/L)was 763 cases(91.15%).Patients with pancytopenia were mainly distributed in Department of Haematology, Department of Emergency, Department of Respiratory Medicine, Department of General Surgery,Department of Gastroenterology,Department of Cardiology and other departments.According to the etiology, the 836 patients were divided into 287 cases (34.33%) of hemotopathy and 488 cases (58.37%) of non-hemotopathy.In hematopoietic system, megaloblastic anemia mainly accounted for 35.19%, followed by myelodysplastic syndrome(19.16%). In non-hematopoietic system, infection disease accounted for 34.06%, followed by metastatic tumor (18.5%).The decrease degree of leukocyte, hemoglobin and platelet in hemotopathy was higher than that in non-hemotopathy, the difference was statistically significant(P<0.05).Conclusion Clinicians of all specialties should pay attention to finding the etiology of pancytopenia,and improve the level of diagnosis and treatment. Pancytopenia is mainly caused by hematopoietic disorders, non-hematopoietic diseases also accounts for a certain percentage. Bone marrow cytology and laboratory tests should be actively performed to confirm the diagnosis and avoid missed diagnosis and misdiagnosis.
王欢； 叶芳； 李宁宁； 舒亚南； 童春； 王玲； 张立男. 836例全血细胞减少患者临床特征分析[J]. 中国当代医药, 2022, 29(8): 42-46.
WANG Huan YE Fang▲ LI Ningning SHU Ya′nan TONG Chun WANG Ling ZHANG Linan. Analysis of the clinical characteristics of 836 patients with pancytopenia. 中国当代医药, 2022, 29(8): 42-46.
Vargas-Carretero CJ，Fernandez-Vargas OE，Ron-Magana AL，et al.Etiology and clinico-hematological profile of pancytopenia：experience of a Mexican Tertiary Care Center and review of the literature[J].Hematology，2019，24（1）：399-404.
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