Clinical effect and safety of Nicorandil in the treatment of unstable angina pectoris of coronary heart disease
JIANG Ling1 WU Yuxian2▲ SHEN Xuebin1
1.Department of Cardiology,Nanping First Hospital Affiliated to Fujian Medical University
2.Department of Critical Care Medicine,Quanzhou First Hospital
Abstract：Objective To explore the clinical efficacy and safety of Nicorandil in patients with unstable angina pectoris of coronary heart disease.Methods From October 2019 to September 2020,82 patients with unstable angina of coronary heart disease in Nanping First Hospital were selected as the research objects,and they were divided into a control group and a study group (with 41 cases each) using the random number table method.Patients in the control group were treated with conventional treatment,and patients in the study group were treated with Nicorandil on the basis of the control group.The clinical efficacy,the number and duration of angina pectoris,the incidence of adverse reactions,and the incidence of adverse cardiovascular events were compared between the two groups of patients.Results The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant (P＜0.05).There was no significant difference in the number and duration of angina pectoris before treatment between the two groups (P＞0.05).The number and duration of angina pectoris after treatment in the two groups were lower than those before treatment,the number and duration of angina pectoris in the study group after treatment were lower than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant difference in the incidence of diarrhea,nausea,vomiting,headache and other adverse reactions between the two groups (P＞0.05),and all the adverse reactions were relieved after symptomatic treatment.There was no significant difference in the incidence of adverse cardiovascular events between the two groups (P＞0.05).Conclusion Nicorandil treatment for patients with unstable angina pectoris of coronary heart disease can significantly improve the symptoms of chest tightness,chest pain,fatigue and other symptoms,relieve the onset of angina pectoris,improve myocardial ischemia,and exert significant clinical effects.
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