Abstract：Objective To observe the incidence of adverse reactions in patients treated with injections of anti-tumor drug Paclitaxel in Central Hospital of Wafangdian City,Liaoning Province from December 2017 to December 2019.Methods The clinical data of 130 patients treated with injections of Paclitaxel from December 2017 to December 2019 in the Central Hospital of Wafangdian City,Liaoning Province were retrospectively analyzed,and the incidence of adverse reactions in the patients were observed and analyzed.Results All the 130 patients had adverse reactions of varying degrees,among which the incidence rates of bone marrow suppression (23.08%),alopecia (19.23%) and intestinal reactions (16.92%) were high,and the incidence rates of other adverse reactions such as allergic reactions,joint or muscle pain,blood system diseases,nephrotoxicity,cardiotoxicity and fever were low.In patients of all ages,the incidence of adverse reactions was higher in patients ＞60 years old,accounting for 50.00%.More patients (43.85%) experienced adverse reactions after 8 to 15 days of Paclitaxel treatment.Conclusion Patients treated with the Paclitaxel Injection,the anti-tumor drug,will have adverse reactions of varying degrees,and the high-risk period of adverse reactions is 8 to 15 days after the beginning of the use of Paclitaxel.In the monitoring of drug safety in patients of all ages,special attention should be paid to the specific situation of elderly patients after medication.Prophylactic medication is recommended to reduce the incidence of adverse drug reactions.
盛男. 抗肿瘤药紫杉醇注射治疗患者的不良反应发生情况分析[J]. 中国当代医药, 2022, 29(7): 115-117转121.
SHENG Nan. Analysis of adverse reactions in patients treated with injections of the anti-tumor drug Paclitaxel. 中国当代医药, 2022, 29(7): 115-117转121.
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