Application effect comparison of Cyclopentolate Hydrochloride and Tropicamide in the treatment of hyperopia children with optometry and mydriasis
HUANG Hui1 CHEN Xiaoqin2
1. Department of Ophthalmology, Yichun Maternal and Child Health Hospital, Jiangxi Province, Yichun 336000, China;
2. Xinkangfu Street Community Health Service Center of Yuanzhou District in Yichun City, Jiangxi Province,Yichun 336000, China
目的 比较盐酸环喷托酯与托吡卡胺在远视儿童验光散瞳处理中的应用效果。 方法 选取2020年2月至2021年2月宜春市妇幼保健院收治的78 例行散瞳验光的远光儿童（156 只眼）作为研究对象，根据随机数字表法将其分为观察组和对照组，每组各39 例（78 只眼）。 观察组儿童在行验光时配合使用盐酸环喷托酯散瞳，对照组儿童在验光时配合使用托吡卡胺散瞳。分析两组患儿的屈光度结果，比较两组患儿用药前、用药后20、40、60 min 及用药后24 、48 h 的瞳孔直径和残余调节量的变化，并统计两组的不良反应发生情况。 结果 两组患儿的屈光度结果比较，差异无统计学意义（P＞0.05）。两组用药前的瞳孔直径比较，差异无统计学意义（P＞0.05）；观察组用药后40 min 的瞳孔直径小于对照组，用药后24 、48 h 的瞳孔直径均大于对照组，差异有统计学意义（P＜0.05）。两组用药前的残余调节量比较，差异无统计学意义（P＞0.05）；两组用药后20、40、60 min、24 h 的残余调节量均少于用药前，差异有统计学意义（P＜0.05）。观察组用药后20、40、60 min、24 h 的残余调节量均多于对照组，差异有统计学意义（P＜0.05）。观察组的不良反应总发生率低于对照组，差异有统计学意义（P＜0.05）。结论 在远视儿童验光中，盐酸环喷托酯滴眼液的散瞳效果与托吡卡胺相当，但其睫状肌麻痹效果更优，安全性也更好。
Objective To compare the application effect of Cyclopentolate Hydrochloride and Tropicamide in the treatment of hyperopia children with optometry and mydriasis. Methods A total of 78 hyperoptometry children (156 eyes)underwent dilation optometry admitted to Yichun Maternal and Child Health Hospital from February 2020 to February 2021 were selected as the research objects. They were divided into observation group and control group according to random number table method, with 39 cases (78 eyes) in each group. Children in the observation group were dilated with Cyclopentolate Hydrochloride during optometry, and children in the control group were dilated with Tropicamide.The diopter results of the two groups were analyzed, and the changes of pupil diameter and residual adjustment volume were compared between the two groups before medication, 20, 40, 60 min and 24, 48 h after medication, and the incidence of adverse reactions between the two groups was analyzed. Results There was no significant difference in diopter between the two groups (P＞0.05). There was no significant difference in pupil diameter between the two groups before medication (P＞0.05). The pupil diameter of the observation group at 40 min after medication was smaller than that of the control group, and the pupil diameters of the observation group at 24 and 48 h after medication were larger than those of the control group, with statistically significant differences (P＜0.05). There was no significant difference in the residual regulation before medication between the two groups (P＞0.05). The residual regulatory amounts of the two groups at 20, 40, 60 min and 24 h after medication were lower than those before medication, with statistically significant differences (P＜0.05). The residual regulatory amounts in observation group at 20, 40, 60 min and 24 h after medication were higher than those in control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The mydriatic effect of Cyclopentolate Hydrochloride Eye Drops is similar to that of Tropicamide, but its cycloplegia effect and safety are better.
黄慧；陈晓琴. 盐酸环喷托酯与托吡卡胺在远视儿童验光散瞳处理中的应用效果比较[J]. 中国当代医药, 2022, 29(5): 112-115.
HUANG Hui；CHEN Xiaoqin. Application effect comparison of Cyclopentolate Hydrochloride and Tropicamide in the treatment of hyperopia children with optometry and mydriasis. 中国当代医药, 2022, 29(5): 112-115.
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