Objective To approach correlation of family balance,psychological capital and occupational stress for paramedic in the intensive care unit.Methods A total of 80 cases paramedic in Intensive Care Unit,the Affiliated First Hospital in Fujian Medical University from February 2021 to February 2022 were selected as objects,the paramedic in the intensive care unit occupational stress score and occupational stress scale norm were compared,the correlation of each dimension score of occupational stress scale and work-family balance of occupational stress scale,psychological capital of occupational stress scale were analyzed.Results The career assignment score,individual stress response score of paramedic in the intensive care unit were higher than norm,the differences were statistical significant (P＜0.05).The differently work intrusions family,family intrusions work score and career assignment,individual stress response score were obviously positive correlation,and individual coping resources were obviously negative correlation,work promoted family,family promoted work score and career assignment,individual stress response score were obviously negative correlation,and individual coping resources were obviously positive correlation (P＜0.05).Then self-efficacy,hope psychology,optimism psychology,toughness psychology and career assignment,individual stress response score were obviously negative correlation,and individual coping resources were obviously positive correlation (P ＜0.05).Conclusion The work-family balance,psychological capital and occupational stress of paramedic in the intensive care unit have certain correlation,which could understand influence of different factor for occupational stress,provide sound theoretical basis for guiding clinical nursing.