Abstract：Objective To investigate the clinical efficacy of intra-articular injection of platelet-rich plasma in the treatment of knee joint osteoarthritis. Methods A total of 90 patients with knee joint osteoarthritis who were admitted to Qingdao Traditional Chinese Medicine Hospital from July 2018 to July 2021 were selected, and 90 patients were randomly divided into study group and control group by random number table method, 45 patients in each group. The study group was given intra-articular injection of platelet-rich plasma, and the control group was given intra-articular injection of Sodium Hyaluronate. The clinical effect, knee joint function (Lysholm) score and pain visual analog scale(VAS) score were statistically compared between the two groups. Results The total effective rate of the study group(93.33% [42/45]) was higher than that of the control group (75.55% [34/45]), the difference was statistically significant(P＜0.05). At 1 week, 1 month, 2 months and 3 months after treatment, the VAS score of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). At 1 week, 1 month, 2 months,3 months after treatment, the Lysholm score in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Intra-articular injection of platelet-rich plasma in the treatment of knee joint osteoarthritis has good clinical effects and few adverse reactions, and has important clinical significance for the treatment of patients with knee joint osteoarthritis.
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