注射用血栓通临床应用的主动监测与合理性分析

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摘要目的主动监测注射用血栓通临床应用情况并进行综合评价，为临床安全合理用药、完善药品说明书提供参考。方法基于医院信息系统（HIS）哨点医院药物警戒系统，主动监测连云港市中医院2019年1月至12月住院并使用注射用血栓通的1 688 例患者，对患者基本情况、药品使用信息、药品不良反应（ADR）发生情况和用药合理性进行统计分析。结果监测患者平均年龄（63.08±18.86）岁，男女比例1∶1.07；用药原因主要是脑血管疾病、骨科疾病、肾脏疾病等；在全院84.21%的临床科室使用；平均用药疗程（8.00±5.28）d，日剂量范围150～600 mg/次，均采用每日1 次静脉滴注给药；溶媒主要使用0.9%氯化钠注射液（92.42%）；联合用药品种数共130 种；有7 例发生ADR，发生率为0.41%，主要表现为皮肤及附件损害。不合理用药主要表现在超适应证用药、用药疗程过长、溶媒选择不适宜以及合并使用功效相似药物。结论临床药师基于哨点医院药物警戒系统主动监测注射用血栓通，评价其临床应用合理性及不良反应发生情况。用药患者多为老年人，合并用药品种数多，存在重复用药现象；ADR发生与年龄、合并用药等有关。临床药师应加强患者用药监护，指导临床医生安全合理用药。

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关键词 ：注射用血栓通, 主动监测, 临床应用, 合理性分析, 药品不良反应

Abstract：Objective To actively monitor the clinical application of Xueshuantong for Injection and make comprehensive evaluation, so as to provide reference for clinical safe and rational drug use and improve the drug instructions.Methods A total of 1 688 patients who were hospitalized and used Xueshuantong for Injection from January to December 2019 in Lianyungang Chinese Medicine Hospital were actively monitored based on the pharmacovigilance system of hospital information system (HIS) sentinel hospital pharmacovigilance system. The basic information of patients, drug use information, occurrence of adverse drug reactions (ADR) and rationality of drug use were statistically analyzed. Results The average age of monitored patients was (63.08±18.86) years old, and the male to female ratio was 1∶1.07. The main reasons were cerebrovascular disease, orthopedic disease, kidney disease, etc. It was used in 84.21% of clinical departments in the hospital. The average course of treatment was (8.00±5.28) d, the daily dose ranged from 150-600 mg/time, and all the drugs were administered intravenously once a day. The solvent mainly used 0.9% Sodium Chloride Injection (92.42%). The number of combined drug varieties was 130. ADR occurred in 7 cases (0.41%),mainly manifested as skin and accessory damage. Irrational drug use was mainly manifested in over-indication drug use, long duration of drug treatment, inappropriate choice of solvent and combined use of drugs with similar efficacy.Conclusion Clinical pharmacists actively monitored Xueshuantong for Injection based on the pharmacovigilance system of sentinel hospitals, and evaluated its rationality in clinical application and the occurrence of adverse reactions. Most of the patients were elderly, and the number of combined drugs was large, and there were repeated drugs. The occurrence of ADR was related to age, combined medication and so on. Clinical pharmacists should strengthen medication monitoring of patients and guide clinicians to use drugs safely and rationally.

Key words： Xueshuantong for Injection Active monitoring Clinical application Rationality analysis Adverse drug reaction

基金资助:江苏省药学会——天晴医院药学基金科研项目（Q2019107）；
江苏省连云港市中医院“赵化南”青年科技基金项目（Lzyq1901）。

通讯作者: 李姮（1984-），女，江苏连云港人，硕士，副主任药师。

作者简介: 宋媛媛（1986-），女，江苏连云港人，硕士，副主任药师。

引用本文:

宋媛媛；李姮. 注射用血栓通临床应用的主动监测与合理性分析[J]. 中国当代医药, 2022, 29(27): 130-133.
SONG Yuanyuan；LI Heng. Active monitoring analysis of Xueshuantong for Injection was carried out based on hospital pharmacovigilance system. 中国当代医药, 2022, 29(27): 130-133.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I27/130

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