A meta-analysis of antibody positive rate after nine-valent HPV vaccination
ZHANG Chengfeng1 DONG Yonghai1▲ LIU Yun2 YANG Cheng1
1. Emergency Transmission Center, Jiangxi Provincial Center for Disease Control and Prevention, Jiangxi Province,Nanchang 330029, China;
2. Department of Imaging, Jiangxi Provincial People′s Hospital, Jiangxi Province, Nanchang 330006, China
Abstract：Objective To investigate the rate of antibody positive conversion after 9-valent human papillomavirus(HPV) vaccination by meta-analysis. Methods Randomized controlled trials (RCT) were searched in PubMed, Embase,CNKI, Wanfang and VIP databases for the positive rate of antibody after vaccination with 9-valent HPV vaccine and with quadrivalent HPV vaccine until November 2021. Meta-analysis was performed using Stata 12.0 software. Results A total of 6 RCTs were included. The results showed that there was no statistically significant difference in anti-HPV-6/11/16/18 positive rate between 9-valent HPV vaccine and quadrivalent HPV vaccine after inoculation (P>0.05). The positive rates of anti-HPV-31/33/45/52/58 with nine-valent HPV vaccine were higher than those of quadrivalent HPV vaccine, and the differences were statistically significant (anti-HPV-31: RR=2.10, 95%CI=1.86-2.36; anti-HPV-33:RR-7.99, 95%CI=7.01-9.11; anti-HPV-45: RR=11.03, 95%CI=9.21-13.20; anti-HPV-52: RR=32.17, 95%CI=26.51-39.05; anti-HPV-58: RR=4.96, 95%CI=3.91-6.28). Conclusion Compared with quadrivalent HPV vaccine, nine-valent HPV vaccine has good immunogenicity.
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