Application of Amlodipine Benazapril Tablets (Ⅱ) in elderly patients with hypertension and coronary heart disease
YANG Yanmin1 ZHANG Xia2 BU Xiaojie1 JIA Jingjing1 WANG Hongwei
1. Department of Health Care, Rizhao People's Hospital, Shandong Province, Rizhao 276800, China;
2. Clinical Laboratory, Central Health Center of Nanhu Town of Donggang District of Rizhao City, Shandong Province, Rizhao 276817, China
摘要目的 探讨氨氯地平贝那普利片（Ⅱ）在老年高血压伴冠心病患者中的应用。方法 选取2020年4月至2021年4月日照市人民医院收治的92例老年高血压合并冠心病患者作为研究对象，采用随机数字表法分为参照组与试验组，每组46例。参照组患者给予氨氯地平片口服治疗，试验组患者给予氨氯地平贝那普利片（Ⅱ）口服治疗。比较两组患者治疗前后的24 h平均舒张压（24 h DBP）、24 h平均收缩压（24 h SBP）、内皮素（ET-1）、一氧化氮（NO）水平，并比较两组患者的疗效。结果 两组治疗前的24 h DBP、24 h SBP水平比较，差异无统计学意义（P＞0.05）；两组治疗后的24 h DBP、24 h SBP水平均低于治疗前，差异有统计学意义（P＜0.05）；且试验组治疗后的24 h DBP、24 h SBP水平均低于参照组，差异有统计学意义（P＜0.05）。两组治疗前的ET-1、NO水平比较，差异无统计学意义（P＞0.05）；两组治疗后的ET-1水平低于治疗前，NO水平高于治疗前，差异有统计学意义（P＜0.05）；且试验组治疗后的ET-1水平低于参照组，NO水平高于参照组，差异有统计学意义（P＜0.05）。试验组的治疗总有效率高于参照组，差异有统计学意义（P＜0.05）。结论 氨氯地平贝那普利片（Ⅱ）对于老年高血压伴冠心病患者而言，能更好地控制血压，改善血管内皮功能，对其治疗效果有一定的提升作用。
Abstract：Objective To investigate the application of Amlodipine Benazapril Tablets (Ⅱ) in elderly patients with hypertension and coronary heart disease. Methods From April 2020 to April 2021, 92 elderly patients with hypertension and coronary heart disease admitted to Rizhao People's Hospital were selected as the study objects. They were divided into the reference group and the trial group, with 46 cases in each group. Patients in the reference group were treated with Amlodipine Tablets orally, and patients in the trial group were treated with Amlodipine Beenapril Tablets (Ⅱ) orally. The levels of 24 h mean diastolic blood pressure (24 h DBP), 24 h mean systolic blood pressure (24 h SBP), endothelin-1 (ET-1), and nitric oxide (NO) before and after treatment were compared, and the efficacy of the two groups were compared. Results There was no statistical difference in the levels of 24 h DBP, 24 h SBP between the two groups before treatment (P＞0.05). After treatment, the levels of 24 h DBP and 24 h SBP in the two groups were lower than before treatment, the differences were significant (P＜0.05). The levels of 24 h DBP and 24 h SBP in the trial group after treatment were lower than those in the reference group, the differences were significant (P＜0.05). There were no statistical difference in the levels of ET-1 and NO between the two groups before treatment (P＞0.05). The levels of ET-1 in the two groups after treatment were lower than those before treatment, and the levels of NO in the two groups after treatment were higher than those before treatment, the differences were significant (P＜0.05). Thelevel of ET-1 in the trial group was lower than that in the reference group, and the level of NO in the trial group after treatment was higher than that in the reference group, the differences were significant (P＜0.05). The total effective rate in the trial group was higher than that in the reference group, the difference was significant (P＜0.05). Conclusion For elderly patients with hypertension and coronary heart disease, Amlodipine Beenapril Tablets (Ⅱ) can better control blood pressure, improve vascular endothelial function, and improve its therapeutic effect.
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