Advances in gender differences of psychological stress induced myocardial ischemia
LI Ziyi1 NAN Nan2 SONG Xiantao
1.The Sixth Clinical Medical College,Capital Medical University,Beijing 100069,China;
2.The First Area of Coronary Heart Disease Centre,Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China
Abstract：At present,the research on the gender differences in mental stress induced myocardial ischemia (MSIMI)shows that the gender of patients could be an important factor affecting the incidence and treatment of MSIMI,and the morbidity of female is higher.Many studies have found that the incidence of MSIMI in women is higher than that in men due to coronary artery microcirculation disorders,high platelet reactivity and hormone/inflammatory factors when facing psychological stress.Recent study found that,differ from men,women are prone to have symptoms like angina,anxiety and depression which can aggravate coronary artery microcirculation disorders.These symptoms are considered to be susceptible factors for patients to develop MSIMI.Therefore,relying on the evaluation of the condition of coronary artery microcirculation to predict the occurrence of MSIMI and providing psychological decompression intervention to alleviate the symptoms of female patients are of great significance in the future clinical research.In addition,nuclear medicine examination and echocardiography are mainly used in the diagnosis of MSIMI.Existing studies have shown that the rate of MSIMI in female patients detected by echocardiography is higher than that in men.This article reviews the progress about the mechanism,concomitant symptoms,diagnostic methods and future research direction of gender differences in MSIMI.The purpose of this review is to summarize the existing experience and provide a basis for follow-up clinical research.
van der Meer RE，Maas AH.The Role of Mental Stress in Ischemia with No Obstructive Coronary Artery Disease and Coronary Vasomotor Disorders[J].Eur Cardiol，2021，16：e37.
[3]
Wokhlu A，Pepine CJ.Mental Stress and Myocardial Ischemia：Young Women at Risk[J].Am Heart Assoc，2016，5（9）：e004196.
Rainville JR，Lipuma T，Hodes GE.Translating the Transcriptome：Sex Differences in the Mechanisms of Depression and Stress，Revisited[J].Biol Psychiatry，2022，91（1）：25-35.
[6]
Almuwaqqat Z，Sullivan S，Hammadah M，et al.Sex-Specific Association Between Coronary Artery Disease Severity and Myocardial Ischemia Induced by Mental Stress[J].Psychosom Med，2019，81（1）：57-66.
[7]
Sullivan S，Hammadah M，Al Mheid I，et al.Sex Differences in Hemodynamic and Microvascular Mechanisms of Myocardial Ischemia Induced by Mental Stress[J].Arterioscler Thromb Vasc Biol，2018，38（2）：473-480.
[8]
Quesada O，AlBadri A，Wei J，et al.Design，methodology and baseline characteristics of the Women′s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction （WISE-CVD）[J].Am Heart J，2020，220：224-236.
[9]
Vaccarino V，Sullivan S，Hammadah M，et al.Mental Stress-Induced-Myocardial Ischemia in Young Patients With Recent Myocardial Infarction：Sex Differences and Mechanisms[J].Circulation，2018，137（8）：794-805.
[10]
Hammadah M，Alkhoder A，Al Mheid I，et al.Hemodynamic，catecholamine，vasomotor and vascular responses：Determinants of myocardial ischemia during mental stress[J].Int J Cardiol，2017，243：47-53.
[11]
Widmer RJ，Prasad M，Gomaa M，et al.Vascular reactivity to mental stress is associated with poor cardiovascular disease outcomes in females following acute coronary syndrome[J].Coron Artery Dis，2020，31（3）：300-305.
[12]
Bullock-Palmer RP，Shaw LJ，Gulati M.Emerging misunderstood presentations of cardiovascular disease in young women[J].Clin Cardiol，2019，42（4）：476-483.
[13]
van Diemen JJK，van Dijk A，Racca C，et al.The viewing of a "Bloodcurdling" horror movie increases platelet reactivity：A randomized cross-over study in healthy volunteers[J].Thromb Res，2019，182：27-32.
[14]
Anfossi G，Trovati M.Role of catecholamines in platelet function：pathophysiological and clinical significance[J].Eur J Clin Invest，1996，26（5）：353-370.
[15]
Samad Z，Boyle S，Ersboll M，et al.Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease：insights from the REMIT study[J].J Am Coll Cardiol，2014，64（16）：1669-1678.
[16]
Waissi F，Dekker M，Bank IEM，et al.Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia[J].Res Pract Thromb Haemost，2020，4（5）：879-885.
[17]
Zhang L，Bao Y，Wang X，et al.A meta-analysis on the prevalence，ass ociated factors and diagnostic methods of mental stress induced myocardial ischemia[J].Transl Med，2020，18（1）：218.
[18]
Gebhard C.Women and acute coronary syndromes：still up to no good[J].Eur Heart J，2017，38（14）：1066-1068.
[19]
Liu M，Liu J，Zhang L，et al.An evidence of brain-heart disorder：mental stress-induced myocardial ischemia regulated by inflammatory cytokines[J].Neurol Res，2020，42（8）：670-675.
[20]
Gamsakhurdashvili D，Antov MI，Stockhorst U.Facial Emotion Recognition and Emotional Memory From the Ovarian-Hormone Perspective：A Systematic Review[J].Front Psychol，2021，12：641250.
Emami AS，Bairey Merz CN，Eastwood JA，et al.Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease among Women with Suspected Ischemia：The Women′s Ischemia Syndrome Evaluation[J].Heart Mind （Mumbai），2021，5（4）：112-118.
[23]
Seney ML，Glausier J，Sibille E.Large -Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression[J].Biol Psychiatry，2022，91（1）：14-24.
[24]
Liu MY，Yang Y，Zhang LJ，et al.Potential predictors for mental stress-induced myocardial ischemia in patients with coronary artery disease[J].Chin Med J （Engl），2019，132（12）：1390-1399.
[25]
York KM，Hassan M，Li Q，et al.Do men and women differ on measures of mental stress-induced ischemia?[J].Psychosom Med，2007，69（9）：918-922.
[26]
Vaccarino V，Sullivan S，Hammadah M，et al.Mental Stress-Induced -Myocardial Ischemia in Young Patients With Recent Myocardial Infarction：Sex Differences and Mechanisms[J].Circulation，2018，137（8）：794-805.
[27]
Huan N，Yu Y，Wang P，et al.Research progress regarding the diagnosis and treatment of mental stress-induced myocardial ischemia[J].Anatol J Cardiol，2020，24（3）：126-136.
[28]
Vaccarino V，Wilmot K，Al Mheid I，et al.Sex Differences in Mental Stress-Induced Myocardial Ischemia in Patients With Coronary Heart Disease[J].Am Heart Assoc，2016，5（9）：e003630.
[29]
Yang G，Li W，Klupp N，et al.Does tai chi improve psychological well-being and quality of life in patients with cardiovascular disease and/or cardiovascular risk factors?A systematic review[J].BMC Complement Med Ther，2022，22
京公网安备 11010502046607号