Study on the value of combined detection of glycosylated hemoglobin, glycosylated serum protein and C-peptide in the treatment of patients with type 2 diabetes mellitus
HUANG Xincheng1 HE Jie1 ZHANG Haili2 YAO Ye1▲
1. Department of Clinical Laboratory, Nanchang First Hospital, Jiangxi Province, Nanchang 330008, China;
2. Department of Endocrinology, Nanchang First Hospital, Jiangxi Province, Nanchang 330008, China
Abstract：Objective To analyze the application value of combined glycated hemoglobin (HbA1c), glycated serum protein (GSP), and C-peptide (C-P) testing in the diagnosis and treatment of patients with type 2 diabetes. Methods From January to December 2020, A total 50 suspected diabetic patients whose clinical test blood glucose results exceeded the highest value of the threshold in Nanchang First Hospital were selected as the case group, 50 healthy individuals with normal examination results at the same time were selected as the control group. The levels of HbA1c, GSP and C-P in the two groups were detected, and the differences of above indexes between the two groups were observed. The fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) were used as the gold standard. The diagnostic efficacy of HbA1c, GSP, C-P single detection and combined detection were compared. Results The levels of HbA1c and GSP in the case group were higher than those in the control group, and the levels of C-P were lower than those in the control group, with statistically significant differences (P＜0.05). There were significant differences in sensitivity, accuracy and negative predictive value among single detection of HbA1c, GSP, and C-P and combined detection (P<0.05). There were no significant differences in the specificity and positive value among the four detection methods (P＞0.05). Conclusion The combined detection of HbA1c, GSP and C-P ensures the accuracy of diagnosis and treatment, and has the significance of monitoring and guiding the clinical treatment of type 2 diabetes, providing a strong basis for clinical diagnosis and treatment.
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HUANG Xincheng； HE Jie； ZHANG Haili； YAO Ye1. Study on the value of combined detection of glycosylated hemoglobin, glycosylated serum protein and C-peptide in the treatment of patients with type 2 diabetes mellitus. 中国当代医药, 2022, 29(20): 161-165.
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