Abstract：Objective To investigate the clinical effect of Tripterygium Glycoside Tablets combined with Canagliflozin in the treatment of diabetic nephropathy (DN). Methods A total of 80 patients with DN admitted to Department of Nephrology in Beijing Jingmei Group General Hospital from January 2020 to June 2021 were selected as the research objects, and they were divided into the control group (n=40) and the observation group (n=40) according to different treatment methods. The retrospective analysis was used in this study. The control group was treated with Canagliflozin, and the observation group was treated with Tripterygium Glycoside Tablets combined with Canagliflozin. Both groups were treated for three months. The renal function (24-h quantitative of urinary protein [24-UP], blood urea nitrogen [BUN], serum creatinine [SCr]), liver function (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) and white blood cell count (WBC) before and after treatment were compared between the two groups. Results After treatment, the levels of 24-UP, BUN and SCr in the two groups were lower than those before treatment, and the levels of 24-UP, BUN and SCr in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). There were no significant differences in ALT, AST, WBC between and within the two groups before and after treatment (P>0.05). Conclusion The effect of Tripterygium Glycoside Tablets combined with Canagliflozin in the treatment of DN patients is better than that of Canagliflozin alone, and it can improve their renal function to some extent.
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