骨骼肌衰老对腰痛发病的影响

摘要
图/表
参考文献(39)
相关文章 (14)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要腰痛是临床多发疾病，其发病、转归与腰椎稳定性密切相关。腰痛的相关病发机制尚不明确，既往对腰痛发病机制的研究多着重于骨关节系统与神经系统。随着骨骼肌衰老概念的提出以及脊柱生物力学与解剖学的发展，学者们开始着手探究腰部骨骼肌衰老的病理发生机制及其与脊柱病理改变之间的作用机制。研究表明，机体衰老对骨骼肌产生的一系列病理改变，如全身性低度炎症、老年性肥胖、肌少症以及生理生化改变均可能是诱发腰痛的关键因素。基于此，笔者通过对近年相关文献的查阅和研究，从骨骼肌衰老的角度探讨骨骼肌衰老对腰痛发病、转归的影响，并归纳总结出衰老对骨骼肌的影响以及骨骼肌衰老与腰痛发病的相关机制，以期为今后的医学生物学研究提供有效参考。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	金京
	陈艺敏
	林建平
	郭明玲
	苟艳芸
	陈少清
	王宏

关键词 ：腰痛, 衰老, 骨骼肌衰老, 肌少症

Abstract：Low back pain is a common disease, it′s incidence and outcome are closely related to the stability of lumbar spine. The pathogenesis of low back pain is still unclear, and previous studies on the pathogenesis of low back pain mostly focus on the osteoarticular system and nervous system. With the proposal of the concept of skeletal muscle aging and the development of spinal biomechanics and anatomy, scholars began to explore the pathologic mechanism of skeletal muscle aging in the waist and its interaction with pathological changes in the spine. Studies have shown that a series of pathological changes of skeletal muscle caused by aging, such as systemic low-grade inflammation, senile obesity, sarcopenia and physiological and biochemical changes, may be the key factors to induce low back pain. Based on this, through the consult relevant literature and research in recent years, the author trying to discuss the incident of low back pain from the angle of skeletal muscle ageing, and summarize the correlation between skeletal muscle aging in the waist and the low back pain, so as to provide effective reference for the future medical biology research.

Key words： Low back pain Aging Skeletal muscle aging Sarcopenia

基金资助:国家自然科学基金资助项目（81973924）；福建省自然科学基金委员会面上项目（2019J01360）；福建省中青年教师教育科研项目（JAT190260）。

作者简介: 金京（1995-），女，浙江温州人，福建中医药大学康复医学院2020 级中医康复学专业在读硕士生，研究方向：中医康复学临床骨病。

引用本文:

金京；陈艺敏；林建平；郭明玲；苟艳芸；陈少清；王宏. 骨骼肌衰老对腰痛发病的影响[J]. 中国当代医药, 2022, 29(16): 39-43.
JIN Jing；CHEN Yimin；LIN Jianping； GUO Mingling； GOU Yanyun；CHEN Shaoqing； WANG Hong. Effect of skeletal muscle aging on low back pain. 中国当代医药, 2022, 29(16): 39-43.

链接本文:

https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I16/39

[1]	Global Burden of Disease Study 2013 Collaborators.Global，regional，and national incidence，prevalence，and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries，1990-2013：a systematic analysis for the Global Burden of Disease Study 2013[J].Lancet，2015，386（9995）：743-800.
[2]	Hartvigsen J，Hancock MJ，Kongsted A，et al.What low back pain is and why we need to pay attention[J].Lancet，2018，391（10137）：2356-2367.
[3]	Paige NM，Miake-Lye IM，Booth MS，et al.Association of Spinal Manipulative Therapy With Clinical Benefit and Harm for Acute Low Back Pain：Systematic Review and Meta-analysis[J].JAMA，2017，317（14）：1451-1460.
[4]	李威，唐慧玲，秦思茹，等.针刺治疗非特异性下腰痛的研究进展[J].针刺研究，2020，45（8）：682-686.
[5]	Russo M，Deckers K，Eldabe S，et al.Muscle Control and Non-specific Chronic Low Back Pain[J].Neuromodulation，2018，21（1）：1-9.
[6]	Suh JH，Kim H，Jung GP，et al.The effect of lumbar stabilization and walking exercises on chronic low back pain：A randomized controlled trial[J].Medicine（Baltimore），2019，98（26）：e16173.
[7]	Panjabi MM.Clinical spinal instability and low back pain[J].J Electromyogr Kinesiol，2003，13（4）：371-379.
[8]	Goubert D，De Pauw R，Meeus M，et al.Lumbar muscle structure and function in chronic versus recurrent low back pain：a cross-sectional study[J].Spine J，2017，17（9）：1285-1296.
[9]	Finta R，Nagy E，Bender T.The effect of diaphragm training on lumbar stabilizer muscles：a new concept for improving segmental stability in the case of low back pain[J].J Pain Res，2018，11：3031-3045.
[10]	Park SS，Choi BR.Effects of lumbar stabilization exercises on the flexion-relaxation phenomenon of the erector spinae[J].J Phys Ther Sci，2016，28（6）：1709-1711.
[14]	Gladyshev TV，Gladyshev VN.A Disease or Not a Disease?Aging As a Pathology[J].Trends Mol Med，2016，22（12）：995-996.
[19]	Franceschi C，Garagnani P，Vitale G，et al.Inflammaging and′Garb-aging′[J].Trends Endocrinol Metab，2017，28（3）：199-212.
[31]	Vainshtein A，Desjardins EM，Armani A，et al.PGC-1alpha modulates denervation-induced mitophagy in skeletal muscle[J].Skelet Muscle，2015，5：9.
[11]	Puntumetakul R，Saiklang P，Tapanya W，et al.The Effects of Core Stabilization Exercise with the Abdominal Drawing-in Maneuver Technique versus General Strengthening Exercise on Lumbar Segmental Motion in Patients with Clinical Lumbar Instability：A Randomized Controlled Trial with 12-Month Follow-Up[J].Int J Environ Res Public Health，2021，18（15）：7811.
[12]	Hides J，Gilmore C，Stanton W，et al.Multifidus size and symmetry among chronic LBP and healthy asymptomatic subjects[J].Man Ther，2008，13（1）：43-49.
[13]	van Dieen JH，Selen LP，Cholewicki J.Trunk muscle activation in low-back pain patients，an analysis of the literature[J].J Electromyogr Kinesiol，2003，13（4）：333-351.
[15]	Rezus E，Burlui A，Cardoneanu A，et al.Inactivity and Skeletal Muscle Metabolism：A Vicious Cycle in Old Age[J].Int J Mol Sci，2020，21（2）：592.
[16]	Cruz-Jentoft AJ，Bahat G，Bauer J，et al.Sarcopenia：revised European consensus on definition and diagnosis[J].Age Ageing，2019，48（1）：16-31.
[17]	Narici MV，Maganaris CN，Reeves ND，et al.Effect of aging on human muscle architecture[J].J Appl Physiol （1985），2003，95（6）：2229-2234.
[18]	Ferrucci L，Baroni M，Ranchelli A，et al.Interaction between bone and muscle in older persons with mobility limitations[J].Curr Pharm Des，2014，20（19）：3178-3197.
[20]	Frasca D，Blomberg BB.Inflammaging decreases adaptive and innate immune responses in mice and humans[J].Biogerontology，2016，17（1）：7-19.
[21]	Rezus E，Cardoneanu A，Burlui A，et al.The Link Between Inflammaging and Degenerative Joint Diseases[J].Int J Mol Sci，2019，20（3）：614.
[22]	Xia Z，Cholewa J，Zhao Y，et al.Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia：A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention[J].Front Physiol，2017，8：434.
[23]	Girven M，Dugdale HF，Owens DJ，et al.I-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine （TNF-alpha）Stress Via Reduced p38 MAPK Signal Transduction[J].J Cell Physiol，2016，231（12）：2720-2732.
[24]	Aguilar-Valles A，Inoue W，Rummel C，et al.Obesity，adipokines and neuroinflammation[J].Neuropharmacology，2015，96（Pt A）：124-134.
[34]	Tieland M，Trouwborst I，Clark BC.Skeletal muscle performance and ageing[J].J Cachexia Sarcopenia Muscle，2018，9（1）：3-19.
[25]	Shintani T，Higashi S，Suzuki R，et al.PTPRJ Inhibits Leptin Signaling，and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance[J].Sci Rep，2017，7（1）：11627.
[26]	Nozhenko Y，Rodríguez AM，Palou A.Leptin rapidly induces the expression of metabolic and myokine genes in C2C12 muscle cells to regulate nutrient partition and oxidation[J].Cell Physiol Biochem，2015，35（1）：92-103.
[27]	Pareja-Galeano H，Santos-Lozano A，Sanchis-Gomar F，et al.Circulating leptin and adiponectin concentrations in healthy exceptional longevity[J].Mech Ageing Dev，2017，162：129-132.
[28]	Larsson L，Degens H，Li M，et al.Sarcopenia：Aging-Related Loss of Muscle Mass and Function[J].Physiol Rev，2019，99（1）：427-511.
[29]	Fabbri E，Chiles Shaffer-N，Gonzalez-Freire M，et al.Early body composition，but not body mass，is associated with future accelerated decline in muscle quality[J].J Cachexia Sarcopenia Muscle，2017，8（3）：490-499.
[30]	Riuzzi F，Sorci G，Arcuri C，et al.Cellular and molecular mechanisms of sarcopenia：the S100B perspective [J].J Cachexia Sarcopenia Muscle，2018，9（7）：1255-1268.
[32]	Nederveen JP，Joanisse S，Snijders T，et al.Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men[J].J Cachexia Sarcopenia Muscle，2016，7（5）：547-554.
[33]	Hebert SL，Marquet-de Rougé P，Lanza IR，et al.Mitochondrial Aging and Physical Decline：Insights From Three Generations of Women[J].J Gerontol A Biol Sci Med Sci，2015，70（11）：1409-1417.
[35]	Joseph AM，Adhihetty PJ，Leeuwenburgh C.Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle[J].J Physiol，2016，594（18）：5105-5123.
[36]	Matsuo S，Kawakami M，Minetama M，et al.Clinical Features of Sarcopenia in Patients With Lumbar Spinal Stenosis[J].Spine（Phila Pa 1976），2020，45（17）：E1105-E1110.
[37]	Sakai Y，Matsui H，Ito S，et al.Sarcopenia in elderly patients with chronic low back pain[J].Osteoporos Sarcopenia，2017，3（4）：195-200.
[38]	Acharyya S，Villalta SA，Bakkar N，et al.Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy[J].J Clin Invest，2007，117（4）：889-901.
[39]	Sheng Y，Duan Z，Qu Q，et al.Kinesio taping in treatment of chronic non-specific low back pain：a systematic review and meta-analysis[J].J Rehabil Med，2019，51（10）：734-740.