Abstract：Objective To investigate the expression significance of multiple serum tumor markers in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 80 COPD patients admitted to Fuzhou First People′s Hospital from July 2019 to December 2020 were selected as the research objects, and were divided into acute exacerbation group and stable stage group according to stages, with 40 cases in each group, and 40 healthy subjects in the same period were selected as the control group. Carcinoembryonic antigen (CEA), glycochain antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125) and neuron specific enolase (NSE) were detected and compared among the three groups. The correlation between NSE level and CEA, CA19-19 and CA125 levels were analyzed, and the diagnostic value of various serum tumor markers in the acute exacerbation of COPD by single and combined detection were analyzed. Results CEA, CA19-9, CA125 and NSE levels in COPD acute exacerbation group were higher than those in control group and stable group, with statistical significance (P＜0.05). CA19-9 and CA125 in stable group were higher than those in control group, the difference was statistically significant (P＜0.05). NSE levels were negatively correlated with CEA, CA19-19 and CA125 levels, while CA125 levels were positively correlated with CEA and CA19-9 levels.The level of CA19-9 was positively correlated with CEA level (P＜0.05). In single test, the sensitivity of CA125 was higher, reaching 65.0%; CEA had a high specificity, reaching 85.0%. The sensitivity and specificity of CEA, CA19-9,CA125, and NSE were determined, reached 92.5%, 91.3%, respectively. Conclusion COPD acute weighting period was raised in serum tumor markers CEA, CA19-19, CA125, and NSE levels, and detected that it can help to judge patients with COPD in clinical practice to provide a basis for developing scientific treatment programs.
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