中国当代医药
中国当代医药杂志欢迎您 今天是   2025年4月8日星期二
设为首页  加入收藏  联系我们         
 
      首 页    |    本刊简介     |    期刊荣誉     |    编采团队     |    会务培训     |    理事单位     |    下载专区     |    在线留言     |    联系我们     |     返回中国当代医药网
中国当代医药
  论著 本期目录 | 过刊浏览 | 高级检索 |
低分子肝素治疗早发型重度子痫前期患者的疗效分析
刘晶 张亚丽 王宇威 梁葵香▲
滨州医学院附属医院妇产科,山东滨州 256600
Effect analysis of low molecular-weight heparin in the treatment of patients with early onset severe preeclampsia
LIU Jing ZHANG Yali WANG Yuwei LIANG Kuixiang▲
Department of Obstetrics and Gynecology,Binzhou Medical School Affiliated Hospital,Shandong Province,Binzhou 256600,China
全文: PDF (573 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 目的 探讨低分子肝素(LMWH)治疗早发型重度子痫前期(EOSP)患者的疗效分析。方法 回顾性分析2020年1月至2021年9月期间因EOSP 就诊于滨州医学院附属医院的72 例患者的临床资料,将行常规治疗的36 例患者作为对照组,将在常规治疗基础上加用低分子肝素治疗的36 例患者作为观察组。比较两组患者的血压、24 h尿蛋白定量及羊水量,凝血纤溶功能各项指标,脐动脉血流各项指标以及母儿不良结局发生情况。结果 两组治疗前的各项指标比较,差异无统计学意义(P>0.05);观察组治疗后的血压、24 h 尿蛋白定量、血浆纤维蛋白原(FIB)、D-二聚体(D-D)、脐动脉血流各项指标均低于本组治疗前,羊水量、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)均高于本组治疗前,差异有统计学意义(P<0.05)。而对照组治疗后仅有血压、24 h 尿蛋白定量、血浆纤维蛋白原(FIB)和脐动脉血流各项指标低于本组治疗前,羊水量高于本组治疗前,差异有统计学意义(P<0.05);而对照组治疗前后D-D、APTT 和PT 比较,差异无统计学意义(P>0.05)。且观察组治疗后所有指标变化幅度均血压、24 h 尿蛋白定量、FIB、D-D、脐动脉血流各项指标均低于对照组,羊水量、APTT、PT 均高于对照组,差异有统计学意义(P<0.05)。观察组患者母体并发症和新生儿不良结局发生率均低于对照组,差异有统计学意义(P<0.05)。结论 低分子肝素治疗EOSP 疗效显著,可以明显降低患者血压水平及24 h 尿蛋白定量,显著增加羊水量,有效改善凝血纤溶以及脐动脉血流相关指标,逐步逆转已破坏的胎儿-胎盘血流循环以利胎儿宫内生长发育,适当延长孕周,减少母儿不良结局的发生,值得临床推广应用。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
刘晶
张亚丽
王宇威
梁葵香
关键词 早发型重度子痫前期低分子肝素凝血功能指标脐动脉血流指标胎儿-胎盘血流循环母儿不良结局    
Abstract:Objective To explore the diagnosis and treatment of low molecular-weight heparin (LMWH) early onset severe preeclampsia (EOSP) patients curative effect analysis.Methods The clinical data of 72 patients with EOSP who received treatment in Binzhou Medical School Affiliated Hospital from January 2020 to August 2021 were retrospectively analyzed.Thirty six patients receiving conventional treatment were selected as the control group,and thirty six patients receiving low-molecular-weight heparin in addition to conventional treatment were selected as the observation group.Blood pressure,24 h urine protein,amniotic fluid volume,blood coagulation and fibrinolysis function indexes,umbilical artery blood flow indexes and adverse outcomes of maternal and infant were compared between the two groups.Results Each index of two groups of patients before treatment,there was no statistically significant difference(P>0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,plasma fibrinogen (FIB),D-dimer(D-D) and umbilical artery blood flow index of the observation group were lower than before treatment,and the sheep water,activated partial clotting enzyme live time (APTT),prothrombin time (PT) were higher than before treatment,the differences was statistically significant (P<0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,plasma fibrinogen (FIB) and umbilical artery blood flow indicators below of the control group were lower than before treatment,the sheep water was higher than before treatment,the differences were statistically significant (P<0.05).There were no statistically significant difference in D-D,APTT and PT of control group before and after the treatment(P>0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,FIB,D-D and umbilical artery blood flow index of the observation group were lower than those of the control group,and the sheep water,APTT,PT were higher than those of the control group,the differences was statistically significant (P<0.05).After treatment,the incidence of maternal complications and neonatal adverse outcomes in observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion LMWH treatment of EOSP has a significant therapeutic effect,it can obviously reduce the patient′s blood pressure levels and 24 hours urinary protein quantitative,significantly increase the sheep water,effectively improve blood coagulation fibrinolytic related indicators and related parameters of umbilical artery blood flow,it can gradually restore has damaged fetus-placental blood circulation for the growth and development of the fetus in the womb,it also may be extended appropriately gestational age,reducing the occurrence of aderse outcome mother son,worthy of clinical popularization and application.
Key wordsEarly onset severe preeclampsia    Low molecular-weight heparin    Coagulation function index    Umbilical artery blood flow indicator    Fetus-placental blood circulation    Maternal adverse pregnancy outcomes
    
引用本文:   
刘晶;张亚丽;王宇威;梁葵香. 低分子肝素治疗早发型重度子痫前期患者的疗效分析[J]. 中国当代医药, 2022, 29(14): 22-26.
LIU Jing;ZHANG Yali;WANG Yuwei;LIANG Kuixiang. Effect analysis of low molecular-weight heparin in the treatment of patients with early onset severe preeclampsia. 中国当代医药, 2022, 29(14): 22-26.
链接本文:  
https://www.dangdaiyiyao.com/CN/     或     https://www.dangdaiyiyao.com/CN/Y2022/V29/I14/22
中华人民共和国互联网药品信息服务资格证书(京)-非经营性-2016-0092
京ICP备11001767号-6  京公网安备 11010502046607号  互联网药品信息服务资格证  期刊出版许可证  广告经营许可证
信息产业部备案管理系统网址 http://beian.miit.gov.cn/state/outPortal/loginPortal.action
投稿热线:010-59626690 总机:010-59626692/18/19/20   传真:010-59626204   投稿信箱:ddyy@vip.163.com
地址:北京市朝阳区东四环中路78号楼(大成国际中心B1座)8B02室   邮编:100124
技术支持:北京玛格泰克科技发展有限公司
Copyright 2000-2014 版权所有 《中国当代医药》杂志社 未经授权请勿转载