Abstract：Objective To explore the effect of three sequential therapies consisting of Erythromycin,Azithromycin and Erythromycin combined with Azithromycin in the treatment of Mycoplasma pneumoniae pneumonia in children.Methods Retrospectively analyzed the clinical data of 150 children with Mycoplasma pneumoniae pneumonia admitted to the PLA 71st Army Group Hospital from October 2017 to July 2019.According to the medication plan,they were divided into the Erythromycin sequential therapy (HMS) group,the Azithromycin sequential therapy (AQMS) group and the Erythromycin-Azithromycin sequential therapy (HMS-AQMS) group,with 50 cases in each group.In HMS group,Erythromycin was given orally for 3 d after 7 d of intravenous drip.In AQMS group,Azithromycin was given intravenously for 5 d and stopped for 3 d,then orally for 5 d.In HMS-AQMS group,Erythromycin was given intravenously for 7 d and then Azithromycin was given orally for 3 d.The symptoms,signs,X-ray changes,clinical efficacy and adverse reactions of the three groups were compared..Results There were no significant differences in the time of fever abatement,cough disappearance,pulmonary rales disappearance and X-ray examination recovery time among the three groups (P>0.05).The total effective rate of HMS-AQMS group was 96.0%,which was higher than that of HMS group(86.0%) and AQMS group (88.0%),the difference was statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05).Conclusion Erythromycin-Azithromycin continuous therapy in the treatment of children with Mycoplasma pneumoniae pneumonia has better curative effect and lower adverse reactions,so it is worthy of promotion and application in clinical practice.
李艳丽；尚颖；王增慧；洪倩. 三种序贯疗法治疗小儿肺炎支原体肺炎的效果[J]. 中国当代医药, 2020, 27(36): 106-108转112.
LI Yan-li ；SHANG Ying ；WANG Zeng-hui ；HONG Qian. Effect of three sequential therapy on children with Mycoplasma pneumoniae pneumonia. 中国当代医药, 2020, 27(36): 106-108转112.
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