Effect of Glutathione combined with Alprostadil treating acute kidney injury in sepsis
LUO Ju-hui1 XU-Zhong2▲ LONG Xin-cong3 LONG Yong-jian1 HU Hui-lian1
1.Department of Critical Care Medicine，the Second People′s Hospital of Baiyun District in Guangzhou City，Guangdong Province，Guangzhou 510450，China;
2.Department of Critical Care Medicine，the Third Affiliated Hospital of Guangzhou Medical University，Guangdong Province，Guangzhou 510150，China；3.Department of Cardiology，the Third Affiliated Hospital of Guangzhou Medical University，Guangdong Province，Guangzhou 510150，China
Abstract：Objective To explore the effect of Glutathione combined with Alprostadil treating acute kidney injury in sepsis.Methods The clinical data of 80 patients with acute kidney injury in sepsis admitted to the Department of Intensive Medicine of the Second People′s Hospital of Baiyun District，Guangzhou from January 2017 to June 2019 were analyzed retrospectively.According to the different drug treatment methods，they were divided into the combined group and the control group，40 cases in each group.The control group received routine intravenous drip of Alprostadil，10 μg/time，qd;the combined group received glutathione treatment on the basis of the control group，0.6 g/time，qd，both groups were treated for 10 days.The curative effect at 10 days after treatment and the changes in serum tissue plasminogen activator (TPA) and plasminogen activator inhibitor (PAI-1) levels of the two groups were observed;the acute physiology and chronic health scores (APACHE Ⅱ)，systemic infection-related organ failure score (SOFA) were used to assess the changes in patients′ condition.Results The total effective rate of the combined group was higher than that of the control group，the difference was statistically significant difference (P＜0.05);the serum TPA and PAI-1 levels of the combined group were lower than those of the control group，there were statistically significant differences(P＜0.05);the APACHEⅡand SOFA scores of the combined group were lower than those of the control group，the differences were statistically significant (P＜0.05).Conclusion Glutathione combined with Alprostadil can improve the therapeutic effect and reduce the levels of TPA and PAI-1 in patients with acute kidney injury in sepsis.
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