Effect of thoracic paravertebral block combined with general anesthesia on T lymphocyte subsets and tumor markers in patients undergoing lung cancer surgery
QI Xiao-tong1 YU Yuan-bo2
1.Department of Anesthesiology,the Third People′s Hospital of Dalian,Liaoning Province,Dalian 116000,China;2.Department of Ophthalmology Operating Room,the Third People′s Hospital of Dalian,Liaoning Province,Dalian 116000,China
Abstract: Objective To investigate the effect of thoracic paravertebral block combined with general anesthesia on the level of T lymphocyte subsets and tumor markers in patients with lung cancer surgery.Methods A total of 80 patients with lung cancer undergoing radical thoracoscopic surgery for lung cancer who were admitted to the Third People′s Hospital of Dalian from August 2017 to December 2019 were selected as the research objects.They were divided into an observation group (40 cases) and a control group (40 cases) according to the single blind method.The control group was operated with conventional general anesthesia,and the observation group was operated with parathoracic block combined with general anesthesia.The levels of T lymphocyte subsets and tumor markers were compared between the two groups.Results 72 hours after operation,the levels of CD3+and CD4+of T lymphocyte subsets in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).The levels of carbohydrate antigen 199 and neuron-specific enolase in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion Thoracic paravertebral block combined with general anesthesia can effectively improve T lymphocyte subsets and reduce tumor markers in patients undergoing lung cancer surgery.
戚晓彤;于渊博. 胸椎旁阻滞复合全麻对肺癌手术患者T淋巴细胞亚群及肿瘤标志物水平的影响[J]. 中国当代医药, 2020, 27(33): 135-137.
QI Xiao-tong1 YU Yuan-bo2. Effect of thoracic paravertebral block combined with general anesthesia on T lymphocyte subsets and tumor markers in patients undergoing lung cancer surgery. 中国当代医药, 2020, 27(33): 135-137.