Abstract：Objective To investigate the effect of Ziprasidone Mesyate Injection on excited components of the positive and negative syndrome scale (PANSS-EC),behavioral activity rating scale (BARS) scores and adverse reactions in schizophrenia patients with acute agitation symptoms.Methods The clinical data of 67 schizophrenia patients with acute agitation symptoms who were admitted to our hospital from January 2019 to January 2020 were retrospectively analyzed.All the patients were divided into the control group (34 cases) and the observation group (33 cases) according to different treatment methods.The control group was given Haloperidol Injection,and the observation group was given Ziprasidone Meylate Injection.The clinical efficacy,PANSS-EC,BARS scores before and after treatment and the total incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was 90.91%,compared with 88.24% of the control group,the difference was not statistically significant (P＞0.05).The PANSS-EC and BARS scores in two groups after treatment were lower than those before treatment,the differences were statistically significant (P＜0.05).There were no statistical differences in the PANSS-EC and BARS scores between the two groups after treatment (P＞0.05).The total incidence rate of adverse reactions in the observation group (9.09%)was lower than that in the control group,the difference was statistically significant (29.41%) (P＜0.05).Conclusion Ziprasidone Mesilate Injection in the treatment of schizophrenia patients with acute agitation symptoms has better curative effects,whose efficacy is similar to Haloperidol,but it has lower incidence of adverse reactions and better safety.
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