Effect of Low Molecular Weight Heparin Calcium on umbilical artery blood flow indexes of fetal growth restriction
YANG Lin1 WANG Jia-yuan2
1.Department of Obstetrics and Gynecology,Dalian Maternal and Child Health Hospital,Liaoning Province,Dalian 116021,China;
2.Reproductive Center,Dalian Maternal and Child Health Hospital,Liaoning Province,Dalian 116021,China
Abstract：Objective To investigate the effect of low molecular weight heparin calcium on umbilical artery blood flow indexes of fetal growth restriction.Methods A total of 80 pregnant women with fetal growth restriction who were admitted to our hospital from March 2018 to September 2019 were selected,and they were divided into two groups according to random number table method,40 cases in each group.The control group was given routine treatment,and observation group was given Low Molecular Weight Heparin Calcium based on the control group.The umbilical artery blood flow (umbilical artery flow resistance index [RI],umbilical artery peak systolic velocity/diastolic peak velocity [S/D]),maternal coagulation function indexes (activated partial thromboplastin time [APTT],prothrombin time [PT]) and neonatal Apgar score were compared between the two groups.Results There were no statistical differences in the umbilical artery flow indexes between two groups before treatment (P＞0.05).After treatment,the umbilical artery blood flow indexes in two groups were lower than those before treatment,and observation group was lower than control group,the neonatal Apgar score of observation group was higher than that of control group,and the differences were statistically significant (P＜0.05).There were no statistical differences in the maternal coagulation function indexes between two groups before and after treatment (P＞0.05).Conclusion Low Molecular Weight Heparin Calcium in treatment of fetal growth restriction can improve fetal umbilical artery blood flow indexes,increase neonatal Apgar score,and not affect coagulation function of pregnant women,which is worthy of clinical application.
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