Expression and significance of HER4 in gliomas of different pathological grades
ZHANG Xin-juan1 SUN Long2 WANG Hai-feng1 JIANG Xu-guang1
1.Department of Western Medicine Education,Shandong College of Traditional Chinese Medicine,Shandong Province,Yantai 264199,China;
2.Department of Neurosurgery,Linyi Central Hospital,Shandong Province,Linyi 276400,China
Abstract：Objective To study the expression of HER4 in gliomas of different pathological grades.Methods A total of 88 cases of primary gliomas which were removed surgically in Linyi Central Hospital from January 2008 to December 2009 were selected and 14 cases of normal brain tissues from patients with brain injury underwent craniotomy and decompression as control.The expression level of HER4 in normal brain and glioma tissues of different pathological grades was detected by immunohistochemistry.Results The positive expression of HER4 was mainly localized in cytoplasm and nucleus.HER4 highly expressed in gliomas compared with normal brain tissue (P<0.05).The expression of HER4 in low-grade gliomas was higher than that in normal brain tissues (P<0.05),while that in high-grade gliomas was higher than that in low-grade gliomas,the differences were statistically significant (P<0.05).Conclusion HER4 plays an important regulatory role in the occurrence and development of gliomas.HER4 can be used as an important biological index to evaluate the malignant degree of gliomas.At the same time,HER4 can also be used as a new target for gliomas treatment.
张新鹃;孙龙;王海风; 姜旭光. HER4在不同病理分级胶质瘤中的表达及意义[J]. 中国当代医药, 2020, 27(30): 37-39.
ZHANG Xin-juan; SUN Long;WANG Hai-feng;JIANG Xu-guang. Expression and significance of HER4 in gliomas of different pathological grades. 中国当代医药, 2020, 27(30): 37-39.
Lai C，Lemke G.An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system[J].Neuron，1991，6（5）：691-704
[4]
Plowman GD，Culouscou JM，Whitney GS，et al.Ligand-specific activation of HER4/p180erbB4，a fourth member of the epidermal growth factor receptor family[J].Proc Natl Acad Sci USA，1993，90（5）：1746-1750.
Srinivasan R，Poulsom R，Hurst HC，et al.Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types[J].J Pathol，1998，185（3）：236-245.
[6]
Bussu F，Ranelletti FO，Gessi M，et al.Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas：antioncogeniificance c signof the HER4 protein in laryngeal squamous cell carcinoma[J].Laryngoscope，2012，122（8）：1724-1733.
[7]
Liu Y，Song L，Ni H，et al.ERBB4 acts as a suppressor in the development of hepatocellular carcinoma[J].Carcinogenesis，2017，38（4）：465-473.
[8]
Sahu A，Patra PK，Yadav MK，et al.Identification and characterization of ErbB4 kinase inhibitors for effective breast cancer therapy[J].J Recept Signal Transduct Res，2017，37（5）：470-480.
[9]
Arnli MB，Meta R，Lydersen S，et al.HER3 d and HER4 are highly expresse in human meningiomas[J].Pathol Res Pract，2019，215（10）：152 551.
[10]
Ohashi Y，Kumagai K，Miyata Y，et al.Overexpression of ErbB4 is an independent marker for lymph node metastasis in Japanese patients with oral squamous cell carcinoma[J].Oral Surg Oral Med Oral Pathol Oral Radiol，2016，122（3）：313-321.
Wang H，Sun W，Sun M，et al.HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1[J].Biochim Biophys Acta Mol Basis Dis，2018，1864（5 Pt A）：1839-1849.
[16]
Zhu W，Li S，Zou B，et al.Expressions and clinical significance of HER4 and CD44 in sinonasal mucosal malignant melanoma[J].Melanoma Res，2018，28（2）：105-110.
[17]
Feinmesser M，Veltman V，Morgenstern S，et al.Different patterns of expression of the erbB family of receptor tyrosine kinases in common nevi，dysplastic nevi，and primary malignant melanomas：an immunohistochemical study[J].Am J Dermatopathol，2010，32（7）：665-675.
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