Abstract：Objective To investigate the effect of intravitreal injection of Ranibizumab on treatment of ocular fundus disease. Methods A total of 100 patients with ocular fundus disease treated in our hospital from January 2018 to October 2019 were selected as the research subjects and divided into the control group and the observation group by random number table method, with 50 cases in each group. Patients in the control group were treated with conventional drugs, while patients in the observation group were treated with intravitreal injection of Ranibizumab on the basis of conventional drugs. The total effective rate, symptom disappearance time, clinical symptom improvement and hemodynamic indicators were compared between the two groups. Results The total effective rate in the observation group(92.00%) was higher than that of the control group (72.00%), and the difference was statistically significant (P＜0.05).The retinal edema disappearance time, normal retinal thickness recovery time, retinal hemorrhage disappearance time and neovascularity disappearance time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, the eyesight of the observation group was higher than that of the control group, the intraocular pressure and retinal thickness of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, the whole blood viscosity, plasma viscosity, hematocrit and red blood cell aggregation index of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜0.05). Conclusion Intravitreal injection of Ranibizumab has a significant effect on treatment of ocular fundus disease and is worthy of clinical application and promotion.
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