Abstract:Objective To compare the pregnancy outcomes of frozen-thawed embryo transfer at different times after oocyte retrieval, and to explore the earliest transplanting time for frozen-thawed embryo transfer. Methods Retrospective analysis of patients who received in vitro fertilization embryo transfer (IVF-ET) at the Reproductive Medicine Center of Women Health Center of Shanxi from January 1 to June 30, 2018 was conducted. Patients who met the inclusion/exclusion criteria of this study were divided into two groups according to the timing of frozen-thawed embryo transfer(FET), with 75 patients in group A who were given FET at the first menstrual cycle after oocyte retrieval, and 165 patients in group B who were given FET after ovaries recovered to the level before superovulation. Ovarian hyperstimulation syndrome (OHSS) classification, endometrial preparation and pregnancy outcomes were compared between the two groups. Results There was no significant difference in OHSS classification between the two groups after oocyte retrieval(P>0.05). The days of using Estradiol Tablets in group A was shorter than that in group B, and the dosage of Estradiol Tablets was less than that in group B, the differences were statistically significant (P<0.01). The ovarian volume in group A was larger than that in group B on the day of transplantation, with statistically significant difference (P<0.01).There were no significant differences in the clinical pregnancy rate, embryo implantation rate, twin rate, early miscarriage rate, late miscarriage rate, premature birth rate and delivery rate between the two groups (P>0.05). Conclusion FET at the first menstrual cycle after oocyte retrieval does not affect the pregnancy outcomes of patients whose OHSS classification after oocyte retrieval is none, mild and moderate.
梁利霞; 刘俊芬; 范俊梅; 张志平; 张秀萍. 不同时机冻融胚胎移植妊娠结局比较[J]. 中国当代医药, 2020, 27(28): 8-12.
LIANG Li-xia; LIU Jun-fen; FAN Jun-mei; ZHANG Zhi-ping; ZHANG Xiu-ping. Comparison of pregnancy outcomes of frozen-thawed embryo transfer at different timings. 中国当代医药, 2020, 27(28): 8-12.
Healy MW,Patounakis G,Connell MT,et al.Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles?[J].Fertil Steril,2016,105(1):93-9.e1.
[4]
Shapiro BS,Daneshmand ST,Garner FC,et al.Contrasting patterns in in vitro fertilization pregnancy rates among fresh autologous,fresh oocyte donor,and cryopreserved cycles with the use of day 5 or day 6 blastocysts may reflect differences in embryo-endometrium synchrony[J].Fertil Steril,2008,89(1):20-26.
[5]
Shapiro BS,Daneshmand ST,Garner FC,et al.Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization:a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders[J].Fertil Steril,2011,96(2):344-348.
[6]
Evans J,Hannan NJ,Edgell TA,et al.Fresh versus frozen embryo transfer:backing clinical decisions with scientific and clinical evidence[J].Hum Reprod Update,2014,20(6):808-821.
[7]
Ishihara O,Araki R,Kuwahara A,et al.Impact of frozenthawed single-blastocyst transfer on maternal and neonatal outcome:an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan[J].Fertil Steril,2014,101(1):128-133.
[14]
Younis JS,Simon A,Laufer N.Endometrial preparation:lessons from oocyte donation[J].Fertil Steril,1996,66(6):873-884.
[8]
Gameiro S,van den Belt-Dusebout AW,Smeenk JM,et al.Women′s adjustment trajectories during IVF and impact on mental health 11-17 years later[J].Hum Reprod,2016,31(8):1788-1798.
[9]
Golan A,Weissman A.Symposium:Update on prediction and management of OHSS.A modern classification of OHSS[J].Reprod Biomed Online,2009,19(1):28-32.
[10]
Mackens S,Santos-Ribeiro S,van de Vijver A,et al.Frozen embryo transfer:a review on the optimal endometrial preparation and timing[J].Hum Reprod,2017,32(11):2234-2242.
[11]
Gardner DK,Lane M,Stevens J,et al.Reprint of:Blastocyst score affects implantation and pregnancy outcome:towards a single blastocyst transfer[J].Fertil Steril,2019,112(4 Suppl 1):e81-e84.
[12]
Verhaak CM,Smeenk JM,Evers AW,et al.Women′s emotional adjustment to IVF:a systematic review of 25 years of research[J].Hum Reprod Update,2007,13(1):27-36.
[13]
Sathanandan M,Macnamee MC,Rainsbury P,et al.Replacement of Frozen-Thawed Embryos in Artificial and Natural Cycles:A Prospective Semi-Randomized Study[J].Hum Reprod,1991,6(5):685-687.
[15]
Cobo A,de los Santos M J,Castellò D,et al.Outcomes of vitrified early cleavage-stage and blastocyst-stage embryos in a cryopreservation program:evaluation of 3,150 warming cycles[J].Fertil Steril,2012,98(5):1138-1146.e1.
[16]
Escribá M,Bellver J,Bosch E,et al.Delaying the initiation of progesterone supplementation until the day of fertilization does not compromise cycle outcome in patients receiving donated oocytes:a randomized study[J].Fertil Steril,2006,86(1):92-97.
[17]
Borini A,Dal Prato L,Bianchi L,et al.Effect of duration of estradiol replacement on the outcome of oocyte donation[J].Assist Reprod Genet,2001,18(4):185-190.
[18]
Soares SR,Troncoso C,Bosch E,et al.Age and uterine receptiveness:predicting the outcome of oocyte donation cycles[J].Clin Endocrinol Metab,2005,90(7):4399-4404.
van de Vijver A,Polyzos NP,Van Landuyt L,et al.Cryopreserved embryo transfer in an artificial cycle:is GnRH agonist down-regulation necessary?[J].Reprod Biomed Online,2014,29(5):588-594.
[21]
Kofinas JD,Blakemore J,McCulloh DH,et al.Erratum to:Serum progesterone levels greater than 20 ng/ml on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates[J].Assist Reprod Genet,2015,32(9):1395-1399.
[22]
Bocca S,Real EB,Lynch S,et al.Impact of serum estradiol levels on the implantation rate of cleavage stage cryopreserved-thawed embryos transferred in programmed cycles with exogenous hormonal replacement[J].Assist Reprod Genet,2015,32(3):395-400.